Currently, coronary artery bypass grafting is the most effective treatment for coronary heart disease and angina pectoris. Coronary artery bypass grafting needs to take autologous saphenous vein as vascular graft material, the current method is to cut the saphenous vein throughout the whole process, the incision is long and traumatic, the incision is not easy to heal, the postoperative scar is obvious, affects the function of the knee joint and aesthetics, and affects the postoperative recovery. Currently, large medical centers in Europe and the United States are using special endoscopic systems to harvest the saphenous vein, which has the advantage of small incision and fast healing, but the special endoscopic equipment is expensive, and the disposable consumables required are very costly, about 17,000 RMB per person. This increase in cost makes it difficult for most patients to accept, thus limiting the development of this new technology. Minimally invasive laparoscopic removal of the saphenous vein for coronary artery bypass grafting has the advantages of small endoscopic incision, no obvious scar, and no impact on the function of the knee joint, without the purchase of expensive equipment, and the disposable consumables are only 1/10 of the cost of special endoscopic consumables. This ensures the long-term patency of the bridge vessels after CABG and the long-term patient outcome. The minimally invasive harvesting of the saphenous vein for coronary artery bypass grafting by general laparoscopy is effective and saves the patient a lot of medical cost, so more and more patients are coming to us for treatment. Case introduction: The patient was 62 years old, suffering from coronary heart disease and angina pectoris, and the angiogram showed multiple lesions of coronary arteries and diabetes mellitus, so he needed coronary artery bypass grafting. Professors Bi Yanwen and Sun Wenyu of the Department of Cardiac Surgery used general laparoscopy to minimally invasively resect the saphenous vein, making an incision of only 2 cm above the knee joint, freeing the full length of the saphenous vein under the endoscope, and removing the saphenous vein from the body, obtaining a length of 40 cm of saphenous vein with high quality. Then coronary artery bypass grafting (4 branches) was performed under minimally invasive heart beat without extracorporeal circulation. He recovered well after the operation and was discharged from the hospital with 8 days of healing.