Leg cramps after cerebral thrombosis should be treated according to different causes. If it is secondary epilepsy, use antiepileptic drugs; if it is hypocalcemia then calcium supplements are needed; if it is caused by high dystonia, dystonia-relieving drugs can be given. 1. Epilepsy: If the affected leg convulsions occur after massive cerebral thrombosis or cerebral thrombosis in the cortical area, EEG is needed to determine whether there is any epileptic seizure. If the EEG confirms secondary epilepsy, carbamazepine or sodium valproate can be given as oral antiepileptic drugs to relieve the symptoms. 2. Hypocalcemia: After cerebral thrombosis, the overall condition of the patient is relatively poor, and the patient can not eat or rely on nasal feeding diet, which will cause nutritional absorption and intake obstacles, and it is easy to cause hypocalcemia, which needs to improve the electrolyte-related tests. If the leg cramps are caused by hypocalcemia, the symptoms can be relieved after calcium supplementation. 3. High muscle tone: After cerebral thrombosis, the affected side of the limb has high muscle tone and active reflexes, so it is easy to have muscle spasms and twitching symptoms, and it can be given to alleviate the muscle tone with medicines such as baclofen to relieve the symptomatic treatment. After the cerebral thrombosis leg cramps, need to improve the relevant examination tests, clear cause of the disease in the doctor’s guidance under the standardization of drug treatment.