Ma, a 58-year-old patient from Bozhou, and Zhu, a 66-year-old patient from Anqing, recently had frequent blood in their urine and were both diagnosed with bladder tumors in local hospitals. Due to the large number of tumors in the bladder, the entire bladder needed to be removed surgically, and the ureter was attached to the belly, so the patient had to urinate from the belly in the future. The two patients came to our urology department with a strong desire to “urinate on their own”, and our specialists performed laparoscopic radical cystectomy + in situ neo-bladder reconstruction to remove the patients’ bladders and create “neo-bladder” using their own intestinal tubes. The patients’ problems were solved by removing their bladders and creating “new bladders” using their own bowel. Two patients had multiple tumors of 2-4 cm in diameter growing in their bladders, which were clearly diagnosed as malignant bladder tumors by the Department of Urology of our hospital. Due to the late detection of the tumors, their large number and huge size required total cystectomy. Considering the patient’s young age and long life expectancy, and his strong desire to urinate through the urethra, after repeated communication with the patient and his family, the urology department planned to perform laparoscopic radical cystectomy + in situ neobladder reconstruction for him. After careful arrangement and preparation, Director Yu Dexin of the Department of Urology of the Second Affiliated Hospital of Anhui Medical University successfully operated on both patients, removing the tumor-filled bladder laparoscopically and then using the patients’ own intestinal tubes to create a “new bladder” for them, so that their bladders were The patients were then given a “new bladder” using their own intestinal tubing, which allowed them to “lose their bladder” and eventually achieve their desire to “urinate on their own. Studies have shown that laparoscopic cystectomy is the standard of care for invasive bladder cancer because it has the advantages of less trauma, less bleeding, earlier time out of bed, less pain, and faster recovery. In contrast, in situ neobladder reconstruction, the surgeon uses the patient’s own bowel to create a “neobladder” through careful suturing, which functions like a normal bladder, and connects it to the patient’s urethra to achieve basic normal urination after surgery. The perfect combination of laparoscopic cystectomy and in situ neo-bladder reconstruction will greatly reduce the patient’s post-operative pain. Our urology department has long made minimally invasive as a specialty of the department, and has matured in all types of minimally invasive urological surgery, which accounts for more than 80% of the total surgical volume of the department, including laparoscopic cystectomy + ileal cystostomy with abdominal wall stoma has been completed in more than 60 cases. The use of intestinal tubes to create a urinary storage sac for patients with a function similar to that of a bladder solves the problem of postoperative urination in cystectomy patients. It is reported that this technology is a leading level in Anhui Province, filling the gap in this field in our hospital and bringing hope to the majority of bladder tumor patients.