Patients with meningioma can be treated with Gamma Knife, but it has some side effects. However, the side effects are relatively milder than open surgery, and one of the side effects is the manifestation of headache. There are two main factors that can cause this: First, gamma knife irradiation will cause necrosis of brain tissue cells, and sometimes may cause necrosis of normal nerve cells, which will create a state of intracranial swelling, and then intracranial hypertension and cause headaches. Second, once the tumor cells and normal cells are necrotic will decompose and release certain chemicals, which will stimulate the meninges and also form the feeling of headache, so it is most common in the clinic. After gamma knife irradiation, some benign meningioma cells have the possibility of becoming malignant, that is, stimulating differentiation. This may lead to metastasis, recurrence or rapid enlargement of the meningioma, which is also unfavorable to the patient, so it is important to distinguish the pros and cons and decide on a treatment plan early.