College students are adolescents, and among those infected with HIV, adolescents are the ones with higher incidence. Therefore, first of all, we need to strengthen sex education for teenagers, and they need to know self-respect, self-love and self-cleanliness, avoid having sex too early and not having too many sexual partners. It is important to have a sense of self-protection in sexual life and refuse to have sex with people who have been infected with AIDS, otherwise it is very easy to be infected. Condoms can play a preventive role to some extent, but they cannot completely prevent the spread of AIDS. Therefore, college students should focus mainly on their studies and should not start having sex too early or have too many partners, as this can easily lead to the spread of HIV. AIDS is mainly transmitted through blood and sex, and sexual transmission is the most important way. In addition, close contact, including saliva contact with wounds in the mouth, can cause the transmission of AIDS.