At present, no state-of-the-art medical center in the world and no experienced physician can make an accurate differential diagnosis of Parkinson’s disease and Parkinson’s syndrome 100% of the time while the patient is still alive. This is because the most reliable diagnosis of Parkinson’s disease is based on pathology slides obtained at autopsy, which is not possible while the patient is alive. Therefore, doctors can only make a clinical diagnosis on the basis of the patient’s clinical manifestations combined with some conventional auxiliary examination means, and on the basis of excluding some similar diseases. The current diagnosis mainly relies on the judgment of clinicians. The complexity of the clinical condition makes it easy to be misdiagnosed and underdiagnosed. Same disease, different symptoms: Parkinson’s disease is divided into tremor type and tonic type, which are easily confused with Parkinson’s syndrome. Different diseases with the same symptom: Parkinson’s disease, idiopathic tremor, progressive supranuclear palsy, multisystemic atrophy P-type, etc. According to the survey, in 2011, the correct self-diagnosis rate of Parkinson’s disease patients in Shanghai only accounted for 53.3%; the match rate between clinical diagnosis of PD and pathology of neurologists and geriatricians was only 76%; the match rate between clinical diagnosis of PD and pathology of movement disorders specialists could reach 98.6%. This shows that the correct diagnosis rate of movement disorder specialists is significantly higher.