Artificial urticaria should not be vaccinated with Neoguan vaccine if it is in the acute stage, but can be vaccinated with a doctor’s consent when it is in remission. Artificial urticaria, also known as cutaneous urticaria, is a condition in which the patient has a heightened physiologic response to a weak external mechanical stimulus, resulting in the production of skin tingling. If there is an acute onset of artificial urticaria, such as large areas of cutaneous scaling, the patient should not be vaccinated with the New Crown vaccine. Vaccination at this time may not only exacerbate the disease, but also make it impossible to distinguish between the disease and the allergic reaction if an allergic skin reaction occurs, thus affecting treatment. If the skin disease is under control after scientific treatment and there is no recurrence in the near future, it is relatively safe to consult your doctor and get his/her consent for the vaccination.