Genital herpes is a sexually transmitted disease caused mainly by herpes simplex virus type II. It manifests itself as clusters of small blisters on the pubic or perianal area, followed by erosion and superficial ulcers. Primary genital herpes is painful, often accompanied by enlarged inguinal lymph nodes, pressure and fever, headache, malaise and other systemic symptoms. Recurrent genital herpes has milder systemic symptoms and rash, with a short duration and mild local burning, pins and needles sensation or abnormal sensation before the rash appears. According to the different clinical manifestations, genital herpes is clinically classified into 3 types: primary, recurrent and subclinical. (1) primary infection is primary; (2) recurrent genital herpes is called recurrent genital herpes within 1 to 4 months after the primary genital herpes rash subsides; (3) asymptomatic or atypical rash, only minor skin fissures and ulcers in the genital area is called subclinical genital herpes, this type accounts for 50% to 80% of the incidence of genital herpes. In recent years, the incidence of genital herpes has increased year by year, and in Western countries, genital herpes is the 3rd most common sexually transmitted disease after non-gonococcal urethritis and gonorrhea. Because of the immunity of the body and the difficulty of drugs to eradicate the herpes simplex virus, the disease is very prone to recurrence, and some scholars call it a hard-to-cure sexually transmitted disease. Genital herpes caused by herpes simplex virus type II is closely related to the occurrence of genital tumors such as cervical cancer, and can increase the chance of HIV infection, and newborns can be infected through the placenta and birth canal, so it should be actively prevented. The current treatment for genital herpes lacks specificity and does not yet address the root cause of its recurrence. The goal of treatment is to relieve symptoms, reduce pain, shorten the course of the disease, reduce viral emissions, and prevent complications and secondary infections. The treatment of genital herpes is mainly antiviral therapy, combined with immunotherapy and local medication is expected to improve the efficacy; Chinese medicine also has certain advantages in the prevention and treatment of genital herpes. (A) systemic therapy 1, antiviral therapy without cyclic guanosine (also known as acyclovir) is recognized as the drug of choice for the treatment of genital herpes, the drug can inhibit the DNA synthesis of the herpes virus, while the impact on the DNA synthesis of the host cell is small, so the drug has few adverse reactions, long-term application has not been found to be obvious accumulation of toxic effects. Primary genital herpes can be taken orally with acyclovir 0.2g once every 4 hours, 5 times a day for 7-10 days. You can also use vancomycin 0.3g orally twice a day or famciclovir 0.25g orally 3 times a day for 7-10 days. The treatment of recurrent genital herpes can be divided into episodic treatment and daily suppressive therapy. Treatment in the flare-up phase is best started within 24 hours of the appearance of prodromal symptoms or lesions with acyclovir, vancomycin, or famciclovir, taken for 5 days at the same dose as above. Daily suppressive therapy can be tried in cases with severe prodromal symptoms and in those with more than 6 relapses per year with psychiatric symptoms (many patients have more frequent relapses in the first few months after the primary infection within 1 year after the initial onset, and daily suppressive therapy should be avoided), and acyclovir 0.4g orally twice daily, or vanaravir 0.3g orally once daily, or famciclovir 0.25g orally twice daily for 4 months to 1 year, and after 1 year treatment is discontinued and observation is given. The application of daily suppressive therapy has been reported to reduce the number of relapses by more than 75% during the treatment period. No toxic side effects have been found with the long-term use of the above drugs, but the blood picture and liver and kidney functions should be checked regularly. It is reassuring to know that as the immunity of the body improves, the number of recurrences of the disease will decrease year by year, and there is no need for patients to spend their lives with antiviral drugs. If the symptoms of primary infection are severe or the rash is extensive, acyclovir 5-10mg/kg body weight can be used as an IV every 8 hours for 5-7 days or until the clinical symptoms subside; those who are resistant to acyclovir and other lovir drugs and immunocompromised can use sodium phosphonate injection 0.3g as an IV once a day, the IV time should not be less than 1 hour and 30 minutes for 7-14 days, and the patient is advised to Drink more water. The use of this drug should prevent its nephrotoxicity and the occurrence of hypokalemia and hypocalcemia, avoid simultaneous use with other nephrotoxic drugs, pregnant women and children should not use this product, elderly patients over 65 years old should use this product with caution, lactating women should suspend breastfeeding during the use of this product. 2, immunotherapy has a lot of data to prove that the recurrence of genital herpes is closely related to immune deficiency, the application of drugs to improve the immune function of patients, can reduce the recurrence of genital herpes. The following immune-enhancing drugs are often used clinically: BCG polysaccharide nucleic acid injection 0.5mg intramuscularly, once every other day, 18 for a course of treatment, generally applied for 1 to 2 courses; glycopyrrolate diamine injection 0.15-0.2g added to 10% glucose 250ml sedation, for 3 weeks; injectable thymidine 10mg intramuscularly, once every other day, for 1 month for a course of treatment, for 1 to 2 courses of treatment. Mannopeptide tablets 10mg can also be used orally 3 times a day for 1 month for 2 to 3 months. It is not yet advocated to treat genital herpes with interferon. The main reason for this is that it is not easy to get rid of the herpes. The formula is based on the different etiology of primary and recurrent genital herpes, primary genital herpes is based on the method of clearing heat and dampness, drying dampness and detoxifying dampness, and the formula is based on the addition and subtraction of gentian diarrhea liver soup; recurrent genital herpes is based on the method of benefiting qi and nourishing yin, clearing heat and dampness, and the medicine is based on astragalus 30g, prunus ginseng 15g, Zhi Mu 12g, Huang Bai 12g, Sheng Di 30g, Da Qing Ye 30g, Pan Lan Gen 30g, Silphium 30g, Fu Ling 30g, Dioscorea 15g, Glycyrrhiza glabra 3g, decoction in water, 1 dose daily. (B) The principle of local treatment is to keep the area clean and dry to prevent secondary infection. The rash can be applied topically with the following drugs: 3% acyclovir cream, 1% penciclovir cream, phthalbutamide application, recombinant human interferon alpha-2b cream, etc. Local corticosteroid preparations are contraindicated, and those with a little exudate in the lesions can be combined with 0.1% Levanox solution wet compresses. The treatment of genital herpes in pregnancy is currently controversial, the focus of the controversy is whether or not Lowe’s drugs can be used in pregnant women and whether or not they can achieve the purpose of controlling recurrence after use, the medical profession currently does not advocate the use of Lowe’s drugs to treat genital herpes in pregnancy. Foreign data show that pregnant women with primary genital herpes have a 20% to 50% incidence of mother-to-child transmission during delivery via the birth canal due to factors such as prolonged viral discharge, frequent involvement of the cervix, large damage area, and the absence of protective antibodies in the body, so a cesarean section is required to prevent mother-to-child transmission. For pregnant women with recurrent genital herpes, the probability of mother-to-child transmission during delivery via the birth canal is 0% to 8% because of the short duration of virus emission, small damage area, and protective antibodies in the body, etc. If there is no active genital herpes at the time of delivery, a cesarean section is not necessary; if there is active genital herpes at the time of delivery, a cesarean section is required; at the end of pregnancy (the last 3 months), although there is a short recurrence, there is no active herpes at the time of delivery The damage can still be delivered vaginally. To avoid the occurrence of genital herpes, the best prevention and control measure is to be clean and to stop having unclean sex. Patients with genital herpes should avoid sexual intercourse during the onset of the disease; if they have sex with others during the non-onset period, they must use condoms. Women with recurrent genital herpes need to have regular gynecological examinations to exclude cervical cancer. Patients with genital herpes should pay attention to rest, avoid strain, maintain emotional stability, quit smoking, alcohol and spicy stimulating food, these measures will help reduce the number of recurrences of genital herpes. Once a recurrence occurs, patients should promptly go to the dermatological venereal disease department of a regular hospital.