The treatment principle of chronic purulent otitis media includes controlling infection, clearing drainage, removing lesions, restoring hearing and eliminating the cause of the disease, etc. The use of of ofloxacin ear drops can control the infection, the use of boric acid glycerin can reduce the inflammatory reaction, and the use of surgical treatment can repair the tympanic membrane and improve the hearing. 1. Congestive stage: use boric acid glycerin and other ear drops to improve inflammation, ephedrine saline nasal puncture to reduce the negative pressure in the middle ear, reduce the inflammation of the middle ear. 2. Exudative stage: in addition to the above medications, antibiotics are also needed to avoid pus, such as ofloxacin ear drops. 3. Purulent stage:Systemic application of sensitive antibiotics to control the infection, such as penicillin and ampicillin. 4.Surgical treatment: middle ear with granulation or polyp, obvious hypertrophy of tympanic mucosa, CT shows soft tissue shadow in mastoid, mastoid opening + tympanoplasty should be performed; middle ear inflammation absorption, leaving tympanic membrane perforation, feasible tympanoplasty. Drugs must be applied under doctor’s guidance. When there is an increase in exudate from the ear canal and hearing loss, it is recommended to consult a doctor in time and follow the doctor’s instructions for standardized treatment.