The specific treatment varies according to the type of severe vaginitis, which mainly includes severe bacterial vaginosis, severe trichomoniasis, severe vulvovaginal pseudomonal yeast disease, severe vaginitis caused by mycoplasma or chlamydia infection: 1. Severe bacterial vaginosis: the drug of choice is metronidazole, also available as clindamycin, tinidazole, treated by oral therapy or local suppositories, lactation Topical medication is recommended. For those who cannot tolerate metronidazole or are allergic to it, or for pregnant women, clindamycin can be used. 2. Severe trichomoniasis: It may be combined with other infections, so local medication is not easy to cure and oral medication is needed for systemic treatment. In addition, this disease is a sexually transmitted disease, sexual partners need to be treated together and avoid sexual intercourse during treatment. 3. severe vulvovaginal pseudomonal yeast disease: simple vulvovaginal pseudomonal yeast disease can be treated with local medication, including clotrimazole suppositories, miconazole suppositories or bacteriocin suppositories, etc. Systemic medication is commonly used for fluconazole. Oral medications, such as fluconazole and itraconazole, are available for unmarried women and for patients who cannot tolerate topical vaginal administration. For recurrent severe vulvovaginal pseudomonal yeast disease, drugs are selected based on drug sensitivity testing. In patients with severe vulvovaginal pseudomycosis during pregnancy, oral azole drugs are prohibited and intravaginal topical drugs such as clotrimazole are preferred. 4. Severe vaginitis caused by mycoplasma and chlamydia infection: drugs such as erythromycin can be taken under the guidance of a doctor, while paying attention to the need for sexual partners to be treated together and diligent change of underwear to prevent recurrent infections.