According to the World Health Organization (WHO) standards, sperm density <20×106/mL is called oligospermia, in which only 1 to 2 spermatozoa are seen in the semen centrifugal sediment under high magnification is called severe oligospermia. In contrast, spermatozoa of class a < 25% and spermatozoa of class a + b < 50% are called weak spermatozoa. It has been confirmed that the azoospermia factor on the long arm of Y chromosome has an important correlation with spermatogenesis, and its microdeletion can lead to non-obstructive azoospermia and severe oligospermia, but its specific mechanism has not been elucidated. In Chinese medicine, there are no records of "oligospermia" or "weak spermatozoa", but they are equivalent to "low spermatozoa", "clear spermatozoa" and "cold spermatozoa". The descriptions of "spermatozoa", "cold sperm", "cold sperm" and so on. Professor Xu Fusong [5], a famous male specialist, believes that oligospermia has the following characteristics: it is the most common among male infertility; it belongs to the category of relative infertility; and Chinese medicine has more satisfactory efficacy in treating this disease. During the period of clinical treatment with Associate Professor Ying Jian, I had the honor to meet a patient with severe oligozoospermia, who was treated by TCM for nearly 4 months and finally conceived successfully. Case introduction: Zhao Moumou, male, 28 years old, IT worker, first consulted on January 15, 2011, consultation number: 2011008629. Complaint: No fertility for more than one year after marriage. The relevant examination results of the Institute of Male Science of Renji Hospital were: semen routine: spermatozoa were occasionally seen (three times on October 22, 2010, December 2, 2010 and December 29, 2010). InhibinB test result: 35.47 pg/ml (reference range: 94 - 327 pg/ml). ultrasound examination showed no significant abnormalities in bilateral testes, epididymis and seminiferous veins. Prostate routine showed: leukocytes: 2-3, lecithin +++. He was diagnosed with severe oligozoospermia at Renji Hospital. He was treated with Chinese and Western medicine for 3 months, but the effect was not obvious, so he came to Longhua Hospital for consultation. He complained of no significant discomfort, acceptable food and nourishment, regulated bowel movements, red tongue with little coating and thin pulse. Specialized examination: normal secondary sexual characteristics, well-developed external genitalia, normal testicular size and texture, no nodules in the epididymis. TCM diagnosis: infertility, evidence of kidney essence deficiency. Treatment is to nourish the kidney and fill the essence. The formula is based on combining Zhi Bai Di Huang Wan with Da Yin Wan. Herbs: Radix Rehmanniae Praeparata 30g, Radix et Rhizoma Tortoise 12g, Radix Rehmanniae Praeparata 12g, Radix et Rhizoma Cyperus 12g, Radix Ziziphiopogonis 10g, Radix Salviae Miltiorrhizae 24g, Radix Chuanjian 15g, Radix et Rhizoma Ligustrum 12g, Radix et Rhizoma Drynariae 15g, Radix et Rhizoma Bark 15g, Radix et Rhizoma Ligustrum 15g, Radix Danpi 9g, Radix et Rhizoma Poriae 30g, Radix Oyster 30g, Radix Astragalus 30g, Radix et Rhizoma Rice 30g, Radix et Rhizoma Cyperus 12g. 28 days. On February 19, 2011, the patient complained of occasional pain in the knee joints bilaterally, the patient's bowel movements were regulated, the tongue was red with little coating, and the pulse was thin. The original formula was supplemented with Chuan Niu Knee 15g and Papaya 15g for 21 days. On April 9, 2011, the seventh consultation, the semen routine review showed that 9% of spermatozoa of grade A, 18% of spermatozoa of grade B, sperm density: 0.12 billion/ml, liquefaction time 55 minutes. After nearly three months of treatment with Chinese herbal medicine, the sperm quality has improved qualitatively compared with that before treatment, although it has not completely reached the standard. The diagnosis was correct, the treatment was appropriate, and the prescription was kept and continued to be taken. The patient complained of thirst. The original formula was supplemented with 12g of Bai Wei and 15g of Chinese wolfberry root bark, which were taken for 28 days. On May 7, 2011, the patient complained of poor sleep in recent days, but no discomfort in the rest of the day, with a normal stomach, regulated bowel movements, red tongue with little coating and thin pulse. The original formula was supplemented with 18g of Radix Polygoni Multiflori, 6g of Schisandra Chinensis and 12g of Sour Jujube Seed. On May 28, 2011, the eleventh consultation, the patient was pleased to report that his wife had successfully conceived. Note: "The Golden Guide to Medicine? It is advisable to always nourish the yin. If yin and yang are in harmony, water can control fire." Zhi Bai Di Huang Wan is a good formula for nourishing Yin and lowering fire, and the Great Tonic Yin Pill is created by Zhu Dan Xi. The two formulas are cut, added and subtracted, and are dedicated to nourishing the true essence, nourishing the kidney and filling the essence. Professor Xu Fusong [5] believes that for reduced sperm count and decreased sperm vitality, there are two main lines of medication: one is to nourish the kidney, and the other is to use more sperm medicine and flesh and blood products. Zong Xu master of medicine, plus the use of Zi He Che powder, Sha Yuan Zi, Chuan break; female chasteberry, dry lotus grass (two to pill), the two taste calm, nourishing the liver and kidney, nourishing Yin and blood without nourishing greasy; ground bone bark, peony bark, Ligustrum, clear heat and detoxify to control the hyperactive false fire; calcined oyster intake of kidney energy, latent upward floating Yang; raw astragalus, raw rice kernel, made yellow essence, Tu Fu Ling, strengthen the spleen and benefit the qi, one to prevent nourishing the kidney products, hinder the spleen transport, the second effect The method of "the first is born from the second, the second nourishes the first", the latter grain enriches the essence of the first; the combined use of all medicines nourishes yin and lowers fire, filling the marrow. After taking the medicine, the patient's symptoms of yin deficiency had been obvious, so she kept the prescription and added and subtracted according to the symptoms, such as bilateral knee pain, that is, adding Chuan Niu Knee and Papaya to induce the downward movement of the medicine. Throughout the whole formula, there is no strange medicine and the treatment method is simple, but the medicine is not afraid of simplicity, the method is not complicated, but the importance is to use the right method. This case was effective because the patient followed the doctor's advice, actively cooperated and persisted in the treatment.