Azoospermia is a condition in which no sperm are found in multiple semen tests (usually more than 3) and is one of the causes of male infertility. There are many causes of azoospermia, and the following multiple conditions are common. Sexual varicocele insufficiency: this can lead to impaired sperm production. Genital injury: factors such as varicocele or trauma surgery can also affect the testicles’ poor blood supply and affect testicular function and lead to sperm production disorders in patients. Radioactive factors: especially radiation or electromagnetic waves can have a great impact on male sperm and affect sperm production. Local high temperature of the testicles: it can affect the production of male sperm, so you need to pay attention to avoid elevated testicular temperature, wear underwear must be loose and breathable. Some systemic diseases such as abnormal thyroid function, abnormal pituitary function, etc. can also affect the production of sperm. There are also some, such as viral mumps, which can also lead to sperm production disorders. Congenital testicular abnormalities. Certain genetic disorders such as autosomal or sex chromosome abnormalities, congenital dysgenesis, etc. Blockage of the vas deferens caused by various reasons. Once you are found to have azoospermia, you must go to the hospital for a comprehensive examination to clarify the cause before doing targeted treatment.