Patients often come to us with positive cervical tests for HPV, especially when the test results are positive for HPV high-risk types. As you can imagine this HPV positivity causes a lot of psychological burden to the patient. In fact, the probability of most people being infected with HPV after having sex is quite high, i.e. the chances of a person being infected with HPV throughout his or her life are high. Most of the virus will be cleared automatically, but very few people will have the virus latent for many years and will have clinically visible lesions or even cancer when their immune function is weak. However, the probability of cancerous changes is usually very small and the process is very long. Therefore, if screening reveals high-risk HPV infection associated with carcinoma, regular cervical examinations, including cervical exfoliation cytology, tissue biopsy pathology, and HPVE7 protein expression, are necessary. Once there are adverse lesions, such as atypical hyperplasia on pathology, or early carcinoma, early treatment is possible to avoid adverse consequences. As to whether cervical high-risk HPV requires treatment, it depends on some of the above-mentioned tests of the cervix. If there is no obvious abnormality, only regular checkups and follow-ups are needed, but if there is histopathological or cytological abnormality, then different treatment stages are needed according to the situation. If there are histopathological or cytological abnormalities, different treatment segments such as photodynamic therapy and partial surgical excision of the cervix are required depending on the situation. Photodynamic therapy helps to remove HPV infected cells has been used to treat HPV positive lesions and precancerous lesions.