A 34-year-old patient, Ms. Jiang, had her pregnancy cleared more than a year ago, and after 4 months of follow-up, everything returned to normal and she was not reviewed regularly. The patient was given standard chemotherapy with methotrexate in a foreign hospital, but the initial effect was acceptable, but the fourth time it was resistant to methotrexate, and then replaced by 5-Fu chemotherapy. The patient failed to find the tumor lesion from the beginning to the end of treatment. If the relevant lesion can be found, surgical excision of the drug-resistant lesion is feasible to achieve a cure. Although the uterus is the most common site of drug-resistant lesions, and the patient has given birth, the patient and family requested hysterectomy, but if the drug-resistant lesions are not in the uterus (for example, in the lung), hysterectomy is not beneficial to the patient, and after full communication with the patient and family, they waited for observation and the emergence of drug-resistant lesions. 10 days later, blood hCG rose from 260mIU/ml to 1923mIU/ml, and ultrasound found drug-resistant lesions. lesion now! The negative 3D ultrasound suggested that it was located in the anterior wall of the uterine fundus (range about 15mm*10mm), and with the chemotherapy, the uterus was removed to take it down in one go! The patient’s HCG returned to normal immediately after surgery, and after 3 courses of consolidation chemotherapy, they were all normal. Chemotherapy is the main treatment for gestational trophoblastic tumors, and the cure rate of chemotherapy is about 85%. For drug-resistant patients (mostly choriocarcinoma), surgical excision of drug-resistant lesions is often required for a possible cure, but the prerequisite is to find out where the drug-resistant lesions are located. If the lesion is not found and the uterus is removed without risk, if the lesion is outside the uterus, it will not only be of no benefit to the patient, but also lose the uterus, increase the cost and increase the harm to the patient. For this patient, the use of lustful tackling, exposure to discover drug-resistant lesions, surgical removal of the uterus (the lesions are in the uterus) or excavation of the lesions, combined with chemotherapy, can often achieve the purpose of curing the disease. Of course, lustful treatment is also a method of last resort and must be taken only after full and informed communication with the patient and her family.