Kidney damage has already occurred in stage 3 diabetic nephropathy and is usually irreversible. The progression of kidney disease can be slowed down by active treatment. In stage III diabetic nephropathy, the first step is to carry out hypoglycemic treatment to control blood glucose in the ideal range. For diabetic patients taking oral hypoglycemic drugs, hypoglycemic drugs with the ability to protect kidney function and reduce urinary protein, such as gliclazide, are preferred. It can also be used with ACEI drugs to protect the kidneys, such as enalapril and benadryl. If oral hypoglycemic drugs cannot be taken, it is recommended to use insulin as early as possible. In addition, the patient’s hypertension, hyperlipidemia, high uric acid and other active symptomatic treatment should be carried out. Patients with diabetic nephropathy are recommended to go to regular hospitals in time and receive standardized treatment under the guidance of doctors.