For patients with Parkinson’s disease, every step can be extremely difficult, and people often use the term “difficult steps” to describe the lives of people with Parkinson’s disease. The onset of Parkinson’s disease is an exceptionally dangerous thing, and many Parkinson’s disease patients will also have the switch phenomenon, so what exactly is the switch phenomenon of Parkinson’s disease? Switching phenomenon refers to the phenomenon of fluctuations in the efficacy of levodopa-like drugs after long-term application of Parkinson’s disease patients, which is a side effect produced by this type of drugs. The main manifestation of “off” is the sudden appearance of limb stiffness and inability to move, like a power failure, for example, when walking, suddenly unable to take a step, as if wearing shackles on the feet and lead hammer, struggling to take a step. At the time of “opening”, although no treatment was added, the activity suddenly became normal and the stiffness of the limbs disappeared, and the patient could move freely. This is a relatively common and difficult complication in the late stage of levodopa treatment, and the mechanism of its control is not well understood. It may be that the receptors produce sharp fluctuations in response to changes in dopamine levels (hypersensitivity state). The use of a dopamine receptor agonist, propargyl amphetamine (Cogentin), may improve symptoms. Prolonged use of a single therapy or a single medication often leads to side effects such as the “switch” phenomenon. Therefore, even if a patient has been diagnosed, he or she should regularly consult a specialist to adjust the treatment plan. Depending on the type and severity of symptoms and the state of impaired function at age, the doctor may be able to reduce these symptoms according to the principle of ‘minimum dose, best effect, long flow, no long-lasting effect’. At present, with the continuous development of technology and improvement of medical level, the emergence of brain pacemaker surgery has received a great response and achieved remarkable results, which is currently recognized internationally as a good treatment method for Parkinson’s disease. Surgery can prolong the “on” time, shorten the “off” time, moderate the sharp fluctuations of “on-off”, eliminate involuntary movements and “end-of-agent” deterioration effects. end-of-dose” deterioration effect. Therefore, the combination of pacemaker surgery and drug therapy can achieve better therapeutic effects and improve the quality of life of patients.