Thyroid hormone insensitivity syndrome is one of the relatively more common of the hormone insensitivity syndromes, first reported by Refetoff et al. in 1967, with a gradual increase in the number of cases reported in the literature since then, although some cases do not have typical features. Treatment: The disease is hereditary and there is no cure. Treatment choices should be made according to the severity of the disease and the different types of patients, maintained throughout life. Mild types are not treated if they are clinically asymptomatic. 1. Thyroid hormone therapy can be applied regardless of the type, and the dose should be adjusted according to the condition in a timely manner. Hypothyroidism can be treated with T4 and iodoserine (T3), especially for infants and adolescents. It can promote growth and development, reduce goiter and TSH secretion, and generally use levothyroxine sodium (L-T4) tablets, and 100-200mg daily of T3 preparations are also effective. For peripheral thyroid hormone insensitive type should be given a larger dose of thyroid preparations can make the condition better. In selective pituitary thyroid hormone insensitive type, the application of T3 treatment not only does not aggravate the patient’s hyperthyroidism symptoms, but also inhibits TSH secretion from pituitary gland due to higher serum T3 level, so that TSH level gradually decreases, the serum thyroid hormone level decreases accordingly, the thyroid gland shrinks and the hyperthyroidism symptoms are reduced. 2. Bromocriptine Dopamine agonist, used to treat selective pituitary thyroid hormone insensitive type, can reduce TSH level. The dose starts from a small dose and gradually increases to normalize the serum TSH, and the serum thyroid hormone level can also be normalized. Other drugs such as dexamethasone and growth inhibitors can be used to suppress TSH secretion in patients with selective pituitary thyroid hormone insensitivity, but they have significant side effects due to long-term application. Caution: For all patients with clinical manifestations, application of treatment for hyperthyroidism, such as antithyroid drugs, isotope iodine, and surgical treatment, should never be used. This is because they are not only ineffective, but also cause irreversible damage to infants and children and aggravate clinical symptoms. In pituitary insensitive patients, TSH secretion is already increased, but the above treatments reduce the level of clear thyroid hormone, which has a weaker negative feedback effect on the pituitary gland, causing TSH cell proliferation in the pituitary gland and potentially leading to TSH tumors.