1, the speed of weight loss should not be too fast, weekly weight loss should not exceed 1.2kg. such as weight loss too fast, but may aggravate liver steatosis, at the same time may appear lactic acidosis and other complications. 2, obesity degree of more than 70% of obesity can first give drug weight loss treatment, wait for weight loss to obesity degree of 50% or less then start exercise therapy. 3, anaerobic metabolism is characterized by static exercise programs and local exercise weight loss is far less effective than aerobic exercise: such as weightlifting, sprinting, basketball, soccer, etc., although also increase the body’s energy consumption but increased glycolysis, muscle glycogen consumption and lactic acid production, resulting in increased blood glucose degradation, free fatty acid consumption is blocked, and lead to hyperphagia. 4, with diabetes, it is generally recommended that 30 to 60 minutes after meals exercise is appropriate, not in the morning when fasting or immediately after the meal to start exercise. Fasting exercise is prone to induce hypoglycemia, type 1 diabetes patients with low fasting insulin levels in the morning, exercise is often not accompanied by an increase in glucose utilization, but rather a significant increase in liver glycogen output, blood glucose, which can aggravate the condition, and even induce ketosis or ketoacidosis, and exercise immediately after meals is likely to affect digestion and absorption. 5, severe insulin-dependent diabetes mellitus (IDDM), exercise can aggravate lipolysis and induce ketoacidosis. 6, diabetic nephropathy, exercise can aggravate proteinuria. 7, diabetic fundopathy, exercise can aggravate the fundus hemorrhage. 8, at the time of the strongest insulin action, such as l1 am should not be physical exercise. If you participate in physical exercise, you must master the method of temporary meal addition to prevent hypoglycemic reaction. Also avoid physical activity before eating after insulin injection to prevent the occurrence of hypoglycemia.