I. Pain Intractable pain can have a very harmful effect on human physiological processes and must be treated in time. Indications for surgery: Intractable pain due to advanced malignancy. Other non-malignant intractable pain, including central pain, bilateral pain, visceral pain, etc.: 1. Surgical treatment: 1947 male, Spiegel and Wycis completed the first stereotactic surgery for intractable pain by destroying the midbrain target. Modern stereotactic microelectrode surgery is minimally invasive, safe and reliable: (1) microelectrode recording; (2) electrical impedance measurement; (3) variable frequency (2-3Hz,100Hz) variable voltage, current and wave width microelectric stimulation; (4) experimental reversible disruption. It can rapidly and precisely locate the site, size, volume, shape and relationship with the surrounding important brain tissues (internal capsule, optic tract, etc.) of intracranial lesions, and can rapidly perform precise radiofrequency thermal coagulation destruction of intracranial lesions to balance and repair the neurological function network, commonly used targets: thalamus (VPL, VPM, CM), etc. 2.Efficacy expectation: the efficiency is 50%-80%, and the operation time is 1 hour on average. Most patients can have a liquid diet 2-4 hours after surgery. The next day after surgery, those with milder preoperative conditions can get out of bed. The cost of hospitalization is 30-35,000 yuan. Length of hospitalization 7-10 days. II. Psychiatric disease Chronic schizophrenia with affective disorder or severe impulsive aggressive behavior, who have failed to respond to long-term (more than 2 years) psychotherapy, medication and electroconvulsive therapy. Patients with severe affective psychosis and various types of neurological disorders, such as chronic depression, anxiety, stress and obsessive-compulsive disorder, and phobias, that are prolonged and persistent and ineffective to conservative treatment. Cerebral hypoplasia with enhanced excitability. Temporal lobe epilepsy with severe behavioral disorders. Refractory severe obsessive-compulsive disorder. 1.Surgical treatment Cingulate gyrus destruction, amygdala destruction, neural network repair key point cell transplantation neurorepair 2.Efficacy expectation Surgical efficacy rate is 70%-90%. The cost of hospitalization is 30-35,000 yuan. Hospitalization time is 7-10 days.