Parkinson’s disease is a slowly progressive extrapyramidal disorder clinically characterized by reduced movement, rigidity, tremor and abnormal postural reflexes. Because of its progressive development, untreated patients typically lose mobility within 10 years due to severe muscle rigidity and secondary joint stiffness, and eventually die from complications such as pulmonary infections, urinary tract infections, and decubitus ulcers. Since the onset of Parkinson’s disease is mainly associated with reduced nigrostriatal dopamine secretion, drug therapy is mainly administered with exogenous dopamine replacement (methyldopa), dopamine receptor agonists (bromocriptine), enzyme inhibitors to reduce the catabolism of dopamine in the body (enkatapone, sregiline), antagonists of dopamine-antagonistic neurotransmitters (meperidine vincristine), etc. However, as the patient’s disease progresses, the drug resistance that results from long-term drug use and the side effects that result from increasing drug doses, the patient often cannot tolerate the treatment of these drugs, and even the switch phenomenon, intra-day fluctuation phenomenon, isokinetic symptoms, frozen feet, end-of-dose phenomenon, and other serious side effects. Most patients will choose to stop taking the drugs at this time because they feel that the side effects are more unbearable than the symptoms of the disease itself. Surgery is the only treatment for Parkinson’s disease. The principle of surgical treatment is that the degeneration of neurons in the substantia nigra-striata of Parkinson’s disease leads to imbalance in the conduction of neural pathways, specifically over-activation of the indirect pathways and over-inhibition of the direct pathways. The new balance between the direct and indirect pathways is achieved and the clinical symptoms are relieved. The nuclei commonly used in neurosurgery are: thalamic nucleus, pallidum, and thalamus. Parkinson’s disease (PD) is a progressive neurodegenerative disease, the exact cause of the disease is unknown, there is no effective prevention methods, the disease is generally progressive aggravation, the disability rate is high, and seriously affect the quality of life of patients, because some patients do not know enough about this type of disease, can not be timely consultation, and Loss of work and life ability or even long-term paralysis in bed adds a heavy burden to the family, and the disease is mostly fatal in the late stage due to complications of pulmonary infections, urinary tract infections and decubitus ulcers. Ventral Median Nucleus. The general thalamic floor nucleus is commonly used for pacemaker therapy, which has significant efficacy for tremor, rigidity, and bradykinesia, and rigidity > tremor > bradykinesia. The pallidum can be treated with either disruption or pacemaker therapy, and is effective in improving the syndrome of mainly rigidity and bradykinesia, with rigidity > bradykinesia > tremor. In contrast, destruction of the thalamic ventral intermediate nucleus or pacemaker therapy is only indicated for patients with Parkinson’s disease with predominantly tremor, and can result in complete cessation of tremor after surgery. The procedure: First, a stereotactic frame is installed under local anesthesia at the bedside, and the target site is scanned by magnetic resonance imaging (MRI) in the MRI room. If a pacemaker is used, an intracranial electrode is implanted and fixed properly, and then a pulse generator is implanted under the clavicle after general anesthesia and connected to the intracranial electrode, and the pulse generator is turned on about two weeks after surgery. The duration of surgery is approximately 2 hours for a general disruption and 3.5 hours for a pacemaker. Patients who underwent disruption or implantation of the pulse stimulator during the surgery clearly felt that their stiff limbs became more relaxed and their awkward movements became more flexible. After turning on the pulse stimulator after surgery, the patient’s preoperative symptoms are relieved by about 90% or more, and with a small amount of medication, the patient can basically return to normal and can carry out normal life and study. At present, the surgical treatment of Parkinson’s disease has been widely carried out at home and abroad, and there are tens of thousands of successful cases. The consensus among scholars of neuroscience at home and abroad is that surgery is currently the ultimate and only option for Parkinson’s disease.