Diabetic patients who have been losing weight are recommended to visit the endocrinology department as soon as possible to adjust the glucose-lowering program, and further improve the relevant examinations to exclude other diseases that cause weight loss, as follows: 1. Diabetes mellitus itself may cause weight loss with dry mouth, excessive drinking, polyphagia, polyuria, etc. If the weight has been lost, it is not recommended to choose weight control drugs. For example, biguanides (e.g. metformin), alpha glucosidase inhibitors (e.g. acarbose), SLGT-2 inhibitors (e.g. dagliflozin), GLP-1 receptor agonists (e.g. dulagliflozin), etc. may lead to weight loss, and then it is better to discontinue the above drugs. The best treatment option is to choose intensive insulin therapy, i.e., subcutaneous injection of fast-acting or short-acting insulin (e.g., Mentholatum insulin) before meals and subcutaneous injection of long-acting insulin (e.g., Glycopyrrolate insulin) before bedtime. In addition, blood glucose control can prevent weight loss to a certain extent. 2. Weight loss may not be directly related to diabetes mellitus, but rather a combination of other diseases that cause weight loss, such as hyperthyroidism, malignant tumors, severe gastrointestinal dysfunction, and so on. It is necessary to consult the endocrinology department to further improve the thyroid function, tumor markers, gastrointestinal microscopy and other tests to rule out related diseases and then formulate the next diagnosis and treatment plan. If you feel unwell, please consult a doctor in time.