Epilepsy, commonly known as “crohn’s disease” or “sheep epilepsy”, is a chronic disease in which sudden abnormal discharges of neurons in the brain cause transient brain dysfunction. The most important thing is that you should take medication for life. The following is a detailed answer to this question: 1. Under what circumstances can we consider stopping medication? If a patient with epilepsy has been seizure-free for more than 2 years, the possibility of medication reduction and discontinuation exists. However, whether and how to reduce and discontinue medication needs to be considered in the context of the patient’s type of epilepsy (etiology, seizure type, syndrome classification), previous treatment response and the patient’s personal situation. If the risk of recurrence is low, and if the risks and benefits of drug reduction are fully communicated to the patient or his/her guardian, the patient may be considered for reduction of antiepileptic drugs. 2. Can I stop the medication if I have no seizures for the last 2 years and the EEG is normal? In most cases, if you have been seizure-free for 2 years and your EEG is normal, you can consider discontinuing your medication. However, specific cases should be analyzed according to the clinical situation. In children with BECT, the EEG is normal and there are still epileptiform discharges. 3. Should I stop the medication at once or slowly? In the case of monotherapy, it should take at least 6 months; in the case of polypharmacy, it should take at least 3 months to stop each antiepileptic drug and only one drug at a time; in the case of withdrawal of benzodiazepines and barbiturates, drug withdrawal-related syndrome and/or seizure reappearance may occur, and the withdrawal time should be at least 6 months. 4. If a seizure occurs again during withdrawal, is it necessary to add more medication? If a seizure occurs again during withdrawal, the medication should be restored to the dose that was given once before the dose reduction. 5. Are there any tests to be done before stopping the medication? EEG is an important auxiliary indicator to judge the timing of drug discontinuation. When clinical consideration is given to the reduction of antiepileptic drugs, EEG should be performed to evaluate the risk of seizure recurrence in combination with age, etiology, seizure type and epilepsy syndrome, and treatment course.