Cold urticaria, as a metamorphic reaction to cold stimuli. It should be noted that: 1, try to avoid contact with cold water, chilled items, especially in the hands are hot, sweating body should not be contacted, need to contact as short as possible, the principle of no skin reaction, to adapt, gradually extend the contact time; 2, avoid eating spicy and irritating food, more rest, do not stay up late, fire; 3, adhere to the treatment, give antihistamines such as Petrone 10mg orally once a day The treatment should be given to antihistamines such as Petragynine 10mg orally once a day, immunomodulators such as BCG polysaccharide nucleic acid injection 2ml intramuscularly once every other day, Chinese medicine Yu Ping Feng granules once a packet three times a day, etc. for one month.