Factors leading to the development of acne 1, androgens: androgen secretion increases during adolescence, making sebum secretion hyperactive. Acne is likely to occur in teenagers. The sebaceous glands in the skin are very active during spring and produce a large amount of sebum. 2. Abnormal keratinization of hair follicles and sebaceous gland ducts: Keratinization of hair follicles and sebaceous gland ducts leads to impaired sebum excretion and retention of sebum, resulting in acne. 3, microbial action: Propionibacterium acnes in the hair follicle and acne can multiply, producing lipolytic enzymes, proteolytic enzymes and hyaluronidase. Lipolytic enzymes break down the triglycerides in sebum into free fatty acids. Free fatty acids, proteolytic enzymes, and hyaluronidase stimulate the follicle funnel and acne sac wall, causing spongy degeneration and even the formation of tiny fissures. 4, inflammatory mediators and inflammation: the role of various inflammatory mediators and pathogenic factors, resulting in acne content through the tiny fissure into the dermis caused by perifolliculitis, the formation of inflammatory papules or pustules, perifolliculitis further expansion, inflammation spread to the dermis connective tissue, causing inflammatory granuloma reaction, the formation of nodules. In severe cases, healing scars are left. 5, other: genetics, diet, gastrointestinal dysfunction, menstruation, mechanical stimulation, cosmetics, etc. can also induce the disease. The pathogenesis of acne is the accumulation of dried sebum, dander and bacteria in the pores of the skin to form acne, which prevents sebum from flowing out of the hair follicle opening. If the pores are not completely blocked, blackheads are formed; if they are completely blocked, whiteheads are formed. The bacteria multiply in the pores and break down certain fats in the sebum, further irritating the skin. The irritated blackheads and whiteheads form a rash, often called an acne papule. If infection and irritation increase, abscesses can form. Five factors are the culprits of acne. For acne prevention improperly leading to acne generation, treatment is the first task, and the best treatment for acne depends on the specifics of the condition, so timely consultation at a regular hospital is also required.