Patients often ask: “There are many toxic side effects on the instructions of a certain drug, will there be serious consequences after taking it?” The question is: “Some people have taken certain anti-rheumatic drugs, and as a result, they hurt their liver and kidneys” and so on. In fact, any therapeutic drugs have a certain impact on the human body, but only the severity of the light, we will not produce any adverse consequences, (an overfull meal, can also have adverse effects on the organism), the heavy, it will damage the body’s vital organs, and even lead to the death of people. Generally speaking, the adverse effects of drugs on people will have a small to large, from quantitative to qualitative process, as long as we regularly monitor, when we find small adverse reactions to drugs, to make appropriate treatment, will completely prevent the emergence of unmanageable situation, such as serious liver and kidney function damage, which is one of the reasons why rheumatologists often require patients to regularly check the blood, liver and kidney function. Often encountered some patients long-term use of tretinoin, resulting in amenorrhea for several months or even a lifetime, careful questioning, found that once they take the drug, often effective and then “effective not more square”, have been taking, even if the amount of menstruation becomes less, or menstruation becomes irregular, but also do not look for a doctor. If they had been taking the drug, regular follow-ups, once these signs of adverse reactions appeared, the doctor would have dealt with them appropriately, and this regrettable situation could have been avoided.