With so many pain medications to choose from, there is no one pain medication that is the only good choice. The best drugs are those that have few side effects and can effectively treat pain. Choosing painkillers that work well while having the least amount of side effects is a criterion for judging how good a drug is. Currently analgesics are non-steroidal anti-inflammatory analgesics, which are probably the most common side effects are gastrointestinal reactions, which can lead to direct irritation of the gastrointestinal tract, or mucosal damage, such as people with such diseases as gastric ulcers, which can cause stomach bleeding problems. Others, due to allergic reactions to some specific types of these drugs, also require attention. Although these drugs have side effects, as long as enough attention is paid to them, they are still relatively safe, and they are also relatively easy to purchase and use, and are a good choice for non-cancerous diseases that are not severe. Opioids should be used with caution in non-cancerous pain because of their addictive nature. It is definitely good to choose painkillers that provide effective analgesia. The primary diseases of pain are numerous and vary in degree. Generally speaking, for some pains that are not severe, non-steroidal anti-inflammatory analgesics can be chosen. Some pain caused by neurological diseases may require the choice of drugs with antipsychotic effects such as amitriptyline and gabapentin for better analgesic effect. Cancer pain in the advanced stage of the disease may use opioids to achieve effective analgesia. There is a general standard for the selection of analgesic drugs, which doctors call stepwise medication. The specific use of the drug is judged according to the specific degree of pain and also the medication.