General tenderness can be caused by a variety of circumstances, the severity of different reasons also varies, generally visible physiological factors and disease factors. Physiological factors include excessive fatigue, lack of sleep and excessive emotional stimulation resulting in a state of stress, which can generally be relieved after proper rest, while disease factors are more complex: 1, nutritional factors: malnutrition leading to anemia or hypoglycemia can cause symptoms of generalized weakness; 2, infection factors: after infection with bacteria or viruses, the body undergoes a strong immune response and symptoms of generalized weakness can occur; 3, disease factors. Abnormal thyroid function, diabetes, cardiovascular diseases, respiratory diseases, neurological and muscular system diseases, brain diseases and many other diseases may appear the symptoms of generalized weakness; 4, drug factors: patients taking drugs such as non-steroidal anti-inflammatory drugs, sedative and sleeping drugs, anti-anxiety depressants, etc. will produce some side effects, which can lead to generalized weakness; 5, poisoning factors: some drugs, heavy metals, carbon monoxide The symptoms of generalized weakness should be promptly checked by the hospital for the cause and then dealt with. If the generalized weakness is caused by malnutrition, attention should be paid to the balanced intake of various nutrients in the daily diet; if the generalized weakness is caused by infection, more water should be drunk and proper rest should be taken; for the generalized weakness caused by poisoning and disease factors, immediate medical attention should be sought; for the generalized weakness caused by drugs, the dosage can be appropriately reduced or treated with other drugs instead under the advice of the doctor.