Endometriosis is a common gynecological condition caused by active endometrial tissue that grows outside of the lining and muscle layer of the uterus and bleeds periodically. Lower abdominal non-menstrual pain associated with endometriosis can be treated with medication and surgery. 1.Medication: (1) Pain can be relieved by oral non-steroidal anti-inflammatory drugs such as ibuprofen extended-release capsules and rofecoxib tablets. (2) Pseudopregnancy therapy is not effective in adenomyosis. Drugs such as danazol, 18-methyltriene kynurenine, and GnRH-a can cause artificial menopause and symptomatic relief by inhibiting ovarian function and causing the endometrium to atrophy. After stopping the drugs, the symptoms often return with the return of menstruation. For those who want to have children, it is still to be explored whether the above drug treatment can improve the pregnancy rate. 2. Surgery: Surgery includes conservative surgery and semi-conservative surgery. Conservative surgery means only removing or destroying the lesion and preserving the reproductive function. Semi-conservative surgery refers to removing the endometriosis lesion and removing the uterus at the same time. When a patient experiences endometriosis abdominal pain, the appropriate surgical treatment plan can be selected based on the patient’s condition, age, and fertility. Patients with endometriosis causing non-menstrual pain in the lower abdomen are advised to go to the hospital in time, do relevant examinations and follow the doctor’s instructions to use medication, not to use medication privately, or under the guidance of the doctor’s advice to undergo surgical treatment.