Lipomas that become large and painful should usually be promptly treated with a total lipoma removal. Lipoma is a kind of benign tumor that grows in the subcutaneous tissue of human body, which usually grows slowly and without pain. When the patient is stimulated by inflammation or the body’s lipid metabolism is disturbed, the lipoma may become bigger and press the surrounding nerves and blood vessels to produce pain, which needs to be treated in time. When the lipoma becomes large and painful, the patient should go to the hospital in time for examination, undergo total lipoma excision, and do pathological examination. Most of the patients can recover their health after the resection, and there are few recurrences and sequelae. After the operation, pay attention to keep the wound clean and observe whether there is blood and fluid seepage from the wound. If the pathological examination shows malignant lesions, further chemotherapy (such as adriamycin, cisplatin, cyclophosphamide, vincristine and other drugs) is needed. Patients should pay attention to balanced nutrition, eat less greasy, high fat, high cholesterol food, but also pay attention to more rest, less stay up late, and develop good habits to reduce the adverse stimulation of the organism. If there is any discomfort, follow the doctor’s instructions for treatment.