Diclofenac sodium is a non-steroidal anti-inflammatory analgesic drug, including tablets, suppositories, mastic and other different types, with analgesic, antipyretic and anti-inflammatory effects, mainly used clinically to relieve pain caused by rheumatoid arthritis, gouty arthritis and other joint inflammation, as well as post-surgical pain and fever. The analgesic effect of diclofenac sodium generally takes effect about 30 minutes after the drug is administered, and the duration of the analgesic effect is as short as 4-6 hours and as long as 24 hours, generally about 12 hours, the specific duration of the analgesic effect is related to the drug dosage form and the mode of administration.1. In general, rectal administration has a faster absorption rate, because the drug can quickly reach the intestine to produce effects, so that the effect is faster. And the drug effect is relatively complete, generally 0.5-2 hours to reach the peak drug concentration, that is, the time of more significant efficacy, the main analgesic effect can last about 12 hours; 2, tablets: diclofenac sodium tablets mainly include slow-release tablets and enteric tablets, the peak time of oral slow-release tablets is relatively long, that is, the pain relief effect is relatively long, but the average retention time is greater than that of enteric tablets, that is, the pain relief effect is maintained for a relatively long time. The average retention time is longer than that of the enteric tablets, i.e. the maintenance time of the effect is relatively longer. Due to the relatively stable blood concentration, the pain-relieving effect of diclofenac sodium extended-release tablets can last up to 24 hours. In contrast, the pain-relieving effect of diclofenac sodium enteric-coated tablets can generally last for 4-6 hours. Patients can also apply hot compresses to improve local blood circulation while using diclofenac sodium, and topical blood-activating and pain-relieving drugs can be used as prescribed by the doctor, and the combined effect of multiple treatments may be better. In addition, because this drug is highly irritating to the stomach, long-term use may cause gastric damage, so patients with underlying gastrointestinal diseases should use this drug sparingly or cautiously, and people without contraindications should take it together with drugs that protect the gastric mucosa as prescribed by the doctor.