Leg numbness in lumbar spondylolisthesis is caused by compression of the nerve root or cauda equina after lumbar spondylolisthesis. If the patient’s medical history is not too long and the symptoms are not too severe, the patient is usually advised to rest and given neurotrophic drugs such as methylcobalamin and neuro-decongestant drugs such as Myclobutanil. If the symptoms are severe, mannitol is recommended for treatment. If the patient’s symptoms are not relieved after the above conservative treatment, which affects normal study and work, and if the patient develops muscle weakness and other symptoms, surgery is recommended. Surgical treatment can take the form of minimally invasive treatment as well as traditional open decompression fusion and other treatments, and it is necessary to choose the appropriate treatment according to different conditions and symptoms.