The current medical term for a person who has had 2 or more consecutive spontaneous abortions is recurrent miscarriage. A miscarriage is defined as a termination before 28 weeks of gestation and a fetus weighing less than 1000 grams. The number of patients suffering from recurrent miscarriage is gradually increasing due to environmental and social factors. Currently, only 50% of patients with recurrent miscarriage can be identified as the cause, and about
The causes of recurrent miscarriage can be identified in only 50% of the patients, and about 50% of the patients cannot be identified. Etiology: 1. Chromosomal abnormalities: including chromosomal abnormalities of the couple and embryonic chromosomes. Maternal endocrine disorders: including luteal insufficiency, polycystic ovary syndrome, hyperprolactinemia, thyroid disease and diabetes mellitus. Abnormalities of the maternal reproductive tract: uterine anomalies (unicornuate uterus, bicornuate uterus, double uterus and longitudinal uterus), cervical insufficiency and uterine fibroids (especially submucosal fibroids and intermuscular fibroids larger than 125px). 4, reproductive tract infections: such as Chlamydia trachomatis, Mycoplasma hyopneumoniae causing endometritis or cervicitis can cause miscarriage. 5, abnormal immune function: (1) autoimmunity: antiphospholipid antibody syndrome. (2) Alloimmunity. 6, Pre-thrombotic state. 7.Hereditary thrombotic tendency. 8.Other: such as unhealthy lifestyle. Disease treatment: Different treatment methods are chosen for different causes. For example, chromosomal abnormalities require genetic diagnosis before embryo transfer (third generation IVF); antiphospholipid antibody syndrome requires prednisone treatment; pre-thrombotic state requires heparin treatment, etc.; active immunotherapy can be used for patients with recurrent miscarriage of unknown origin.