In November 2006, I went to Hangzhou to attend the 2005 Scientific and Technological Progress Award and Academic Book Award Presentation Conference of the Chinese Society of Traditional Chinese Medicine, and ran into a classmate from my university days, Wang Mou, who is now the director of the gynecology department of a Chinese hospital in Shandong, specializing in treating infertility in both men and women, and is also quite knowledgeable about habitual abortion in women. During the conversation, I mentioned the popular article of “Habitual miscarriage, please check the antibodies published in Popular Medicine in 2002, which inspired him a lot, and in the future, whenever he encountered patients with habitual miscarriage in the clinic, he checked the antiphospholipid antibodies in addition to the routine gynecological examination, and found that about 30% of patients with habitual miscarriage were positive for antiphospholipid antibodies. For the patients with positive antiphospholipid antibodies, anticoagulation therapy was given on the basis of TCM evidence-based treatment, which significantly improved the success rate of fetal preservation. He then asked why antiphospholipid antibody positivity could cause habitual abortion. What is the progress of research on the treatment of antiphospholipid syndrome? I would like to ask you, a rheumatologist working in the capital, to tell me: Phospholipids are the most abundant lipid-like components in the human body and are the main biochemical components of biological membranes, which have the role of maintaining the structural and functional integrity of cells and cell organelles. Structural phospholipids are not antigenic; free state phospholipids in the blood can maintain the physiological functions of the nervous system, reproductive system, reticuloendothelial system, and coagulation system, and are antigenic. Placental anticoagulant protein is present in large amounts in the placenta, and it has a high affinity for phospholipids. Placental anticoagulant protein is a calcium-dependent phospholipid-binding protein that inhibits phospholipid-dependent activation of factors V, II, IV, and X by binding to phospholipids and inhibiting activation of factor X and thrombospondin. By affecting the expression of placental anticoagulant proteins on the placental villi surface, antiphospholipid antibodies reduce the local anticoagulant capacity of the placenta, leading to placental thrombosis, placental vascular infarction or embolism, and placental insufficiency, causing spontaneous abortion, intrauterine distress, fetal growth retardation, or intrauterine fetal death. Miscarriage due to antiphospholipid syndrome can occur at any stage of pregnancy, but most often occurs after the tenth week of gestation. The fetus usually develops normally up to the tenth week and then develops slowly and miscarries or dies in utero. In 1983, Labble and Walker reported a case of a woman with a history of miscarriage who had a successful pregnancy after combined treatment with prednisone and aspirin, and since then, other scholars have used combined treatment with prednisone and aspirin to significantly increase the success rate of pregnancy. Gatenby et al. found that prednisone combined with aspirin improved pregnancy success, whereas prednisone alone was not effective. Two case reports showed that antiplatelet therapy was also effective. In the Netherlands, the fetal survival rate increased from 18% to 93% in 37 patients with a history of miscarriage treated with aspirin and pansentin, and in the UK, the fetal survival rate increased from 18% to 88% in 42 women treated with aspirin alone. Therefore, the treatment of miscarriage combined with aPL antibodies is similar to the treatment of thrombosis associated with aPL antibodies, both of which can be treated with antithrombotic therapy. Rosove et al. increased the fetal survival rate from 1/28 to 13/14 with subcutaneous heparin injections throughout pregnancy. Because of the side effects of glucocorticoid therapy, intravenous immunoglobulin has been used to successfully prevent miscarriage. Chinese medicine treatment is mainly based on the diagnosis and treatment with some drugs with hormone-like effects such as Andrographis paniculata, Zhi Mu and Glycyrrhiza glabra to improve the treatment effect.