With the use of radiation therapy, chemotherapy and biological targeted therapy, tumor treatment has entered the stage of comprehensive treatment under the recent biomedical model, and malignant tumors have been transformed from incurable to curable diseases. The so-called comprehensive treatment of tumor refers to the planned and rational application of existing treatment means according to the patient’s body condition, pathological type, invasion range (disease stage) and development tendency of tumor, with the aim to increase the cure rate and improve the quality of life of patients. Surgery and comprehensive treatment Surgery eliminates or reduces the tumor by physical methods and can effectively intervene in the tumor in the state of technology permitting, with the advantage of removing the tumor load and achieving symptom reduction in the fastest time, especially for early stage tumors due to their biological characteristics so that patients without micro-metastases can obtain radical treatment. However, it is worth noting that most patients are still difficult to achieve radical treatment by surgery alone because the tumor already has regional or distant micrometastases at the time of surgery. Therefore, some patients need preoperative radiotherapy or chemotherapy before surgery, and some patients need postoperative radiotherapy or chemotherapy for consolidation. At present, comprehensive treatment has made the scope of traditional surgical treatment from large to small, and from severe disability to preservation of organ function and cosmetic surgery, and the surgical operation is more delicate and thorough, and the preoperative estimation of tumor resectability has been emphasized, effectively avoiding and reducing unnecessary dissection and other surgeries. What is more encouraging is that a considerable part of surgeries can now also be performed by non-traditional surgical methods such as interventional, endoscopic, radiotherapy and other physical treatments (radiofrequency, laser, microwave, electrochemistry, argon helium knife, ultrasound). Surgery is developing in the direction of minimally invasive and fine. 2.Radiotherapy and comprehensive treatment Radiotherapy is an important means of tumor treatment, which, like surgery, is also a kind of local treatment. In recent years, due to the application of electronic computer technology and three-dimensional treatment planning system, stereotactic radiotherapy, hyper-segmentation radiotherapy, conformal intensity modulation radiotherapy and other new technologies in radiotherapy, radiotherapy has made great progress. The organic combination of radiotherapy and chemotherapy has formed a local plus overall combined treatment mode, using radiotherapy to eradicate local lesions and chemotherapy to kill lesions in the irradiated field, thus achieving more effective overall treatment. At the same time, chemotherapy sensitization can play a synergistic and additive role to radiation therapy, enhancing the efficacy and protection. In recent years, the new technology of “precise guidance” makes radiotherapy more precise targeting, and gyroscopic radiotherapy is a treatment with such performance, which focuses gamma rays, which are powerful to kill tumors, on the tumor body in three dimensions, so that the tumor tissue is irradiated with extremely high doses to destroy the tumor, while the normal tissue receives very little radiation, which is in line with This is in line with the current goal of radiotherapy to effectively kill tumors and protect normal tissues to the maximum extent. Chemotherapy and comprehensive treatment Chemotherapy is a kind of systemic treatment. Its expected goal is to control residual cancer foci and eliminate microscopic cancer foci to delay and control the recurrence and metastasis of tumors, to regulate and directly kill tumor cells according to the principle of cell cycle dynamics, and to have a curative effect on some chemotherapy-sensitive tumors. However, chemotherapy is exponentially killing, and there is a difference in intensity compared with surgery and radiotherapy, some tumors are not sensitive to chemotherapy, and chemotherapy is essentially a component or continuation of radical treatment. In recent years, the use of interventional, nano, targeted vector and biological chemotherapy techniques, as well as the development of a large number of new anti-cancer drugs with different mechanisms and the continuous improvement of chemotherapy methods, chemotherapy has significantly improved the cure rate of many tumors, and the role of chemotherapy in the comprehensive treatment of tumors has become more and more important. Biological therapy and comprehensive treatment Biological therapy refers to the application of biological substances, biological agents and biological technology in tumor treatment, including cytokines, monoclonal antibodies and their cross-linkages, immunologically active cells, tumor vaccines, gene therapy and so on. In recent years, molecular and immune research is deep, and the technology of gene, immune and multicellular (vascular and lymphocyte) is developing rapidly from laboratory to clinical, among which biologically targeted therapy has become a very important therapeutic tool in tumor treatment, and some of the biological therapies also belong to a kind of adjuvant therapy for tumor, which can enhance or improve the efficacy of other therapies and improve the prognosis to some extent. The status of biological therapy as the fourth major treatment for tumor has been established and has become one of the directions of tumor treatment in the future, which will definitely create a new era of tumor treatment. In conclusion, comprehensive treatment of tumor is a complex and systematic clinical medical engineering, which is a combination of multiple therapeutic approaches reasonably configured on the basis of full understanding of tumor biological characteristics, pharmacokinetics, pharmacokinetics, radiobiology and other disciplines. The purpose of clinical treatment should be clear, the order of application of various methods should be in accordance with the law of tumor cell biology, and the treatment arrangement should be reasonable and require full discussion and consultation among multidisciplinary doctors. Comprehensive tumor treatment needs to follow: the principles of evidence-based medicine and tumor individualization, the principles of treatment cost and efficacy, the principles of both Chinese and Western medicine, and the principles of clinical quality control, and our scientific anti-cancer road will be unhindered!