When aortic coarctation meets pregnancy

  Pregnancy is a commonplace and mysterious event for a woman in her reproductive years. It is common because it is a normal physiological process; it is mysterious because there are all kinds of problems that even the most famous obstetricians cannot predict and explain during the process. What we are talking about today is the extremely rare comorbidities encountered during pregnancy like the “dauphine” —— aortic coarctation.  What is aortic coarctation?  A relatively rare but extremely serious condition that usually presents as severe chest pain with acute hemodynamic compromise. It is an aggressive disease in which blood passes through a fissure in the intima of the aorta, enters the aortic wall and causes separation of the normal arterial wall, creating a true or false lumen. Pregnant women with a long history of hypertension must be highly suspicious of the presence of aortic coarctation once they experience severe pain in the chest and lower back and seek immediate medical help.  Then, a mother-to-be will surely ask if there is a way to prevent it.  The answer is yes, all expectant mothers with Marfan syndrome (or other connective tissue diseases), family history of aortic disease, confirmed aortic valve disease, confirmed thoracic aortic aneurysm or history of previous aortic surgery are in the high-risk group for aortic coarctation.  For these mothers-to-be, we make the following recommendations: 1. Patients with high-risk factors, whether pregnant or not, must be fully aware of aortic coarctation and its consequences.  2.If pregnant, patients should go to an experienced multicenter for further consultation and treatment.  3, Patients need to undergo more rigorous prenatal examinations during pregnancy, with cardiac ultrasound at 4 to 8 weeks and regular MRI examinations to assess the condition and pregnancy risk in a timely manner and to communicate with cardiologists and obstetrics and gynecologists.  4.For a woman with Marfan syndrome, the diameter of the aortic root, which should be an independent high-risk factor to determine the condition and prognosis, is not recommended for pregnancy if it is greater than 45 mm.  5. B-blockers can be used during pregnancy to reduce the dilation of the aorta, thus reducing the risk of aortic tear.  Well, the story of the best “dauphine” is finished. We must pay attention to this rare but dangerous disease and pay enough attention to it, especially to pregnancy checkups. Finally, I wish all mothers-to-be a good pregnancy!