Mycoplasma urealyticum is a pathogen between the size of a virus and a bacterium, mainly hosted in the human genital tract and urethra. It can be carried by normal people but does not cause disease, and the most important means of transmission is still sexual transmission leading to infection. However, not all people who carry Mycoplasma urealyticum are sexually transmitted, and close contact with towels and other bathing items may also lead to infection. Mycoplasma urealyticum is one of the pathogens that cause non-gonococcal urethritis, but 20% to 50% of the population does not have obvious clinical symptoms. Symptoms can occur when the body is immunocompromised, and the accompanying symptoms are mainly discomfort in urination and increased urethral discharge. Mycoplasma solani infection can also cause a decrease in sperm quality or affect the fetus during pregnancy, so premarital and preconception testing is necessary. The main treatment is still antibiotic therapy such as macrolides, and drug resistance is gradually increasing, often requiring combination therapy, usually 2 to 4 weeks of treatment followed by a review, and once detected, it is recommended that both men and women be treated at the same time. In summary, Mycoplasma solani is still mainly sexually transmitted, so it is recommended to be clean, avoid infection, and once detected, promptly assess the symptomatic treatment.