Urological stones include kidney stones, ureteral stones, bladder stones and urethral stones. With the improvement of people’s quality of life and the change of health concept, patients are more willing to accept minimally invasive treatment to avoid the pain of “surgery”. The most advanced ultrasound/pneumatic ballistic lithotripsy system, Swiss EMS ultrasound/pneumatic ballistic lithotripsy system and German pyeloscope and ureteroscope can treat all kinds of complex and difficult urinary stones without surgery. In the past, these patients often required surgical removal of stones, and once they had multiple stones, they required multiple operations to remove the stones, which seriously affected their physical and mental health. At present, for such patients with difficult and complicated stones, minimally invasive treatments such as percutaneous nephrolithotomy and ureteroscopy can be performed through advanced EMS ultrasound/pneumatic compression lithotripsy system to break up the stones and suck out the stone particles at the same time to remove the stones, which greatly shortens the treatment time, not only saves cost but also reduces the patient’s pain. The percutaneous nephrolithoscopy technique is to make a pen-sized hole in the patient’s waist to establish a channel from the skin to the kidney, and then use ultrasound/pneumatic ballistic lithotripsy under the nephrolithoscope to break up the stones and suck them out of the body, which is imaginatively compared to “making a hole to get a stone”. For ureteral stones with a diameter of more than 1 cm, ureteroscopic lithotripsy can be used to fragment the stones and aspirate the particles out of the body. At present, we have successfully performed minimally invasive treatment such as percutaneous nephrolithotomy and ureteroscopic lithotripsy for nearly 100 patients with complicated stones, which is well received by patients. Compared with traditional open surgery, this minimally invasive technique has the advantages of no open surgical incision, less trauma, no injury, less pain, faster recovery, shorter hospital stay, fewer complications, and higher success rate. At present, patients with urinary system stones do not need open surgery to retrieve stones, but can use drugs to remove stones, extracorporeal shock wave lithotripsy, and for larger, multiple, complex stones that have failed extracorporeal shock wave treatment, minimally invasive treatments such as percutaneous nephrolithotripsy and ureteroscopic lithotripsy can also be implemented through intracavitary interventional therapy.