The methods to determine metastatic bone pain of cancer are as follows: 1. Clinically, doctors will perform clinical staging according to the tumor size, lymph node metastasis and distant metastasis of patients. When the tumor progresses to a certain clinical stage, serum alkaline phosphatase examination, bone scan, PET-CT, MRI, etc. will be performed to determine whether there is bone metastasis. 2. If the patient suddenly develops persistent bone pain and the pain worsens at night or at rest, targeted screening should be performed to determine whether there is bone metastasis.