First, anti-inflammatory and pain-relieving drugs: mainly colchicine, ericiclib or glucocorticoids and other drugs, which are used to relieve the pain of rheumatic bone pain; second, disease-controlling drugs: methotrexate, leflunomide, levonorgestrel, diacerein, febuxostat and other drugs, the choice of such drugs should be based on the specific name of the patient’s rheumatic bone pain. The choice of such drugs should be based on the specific name of the patient’s rheumatic bone pain, such as rheumatoid arthritis patients can choose methotrexate, leflunomide, and gouty arthritis patients caused by rheumatic bone pain, it is necessary to continue to take febuxostat; third, biological agents: the treatment of rheumatic bone pain is fast and effective, but expensive.