Genetic breast cancer-ovarian cancer syndrome genetic testing criteriaa, b (1) Carriers of BRCA1/BRCA2 gene mutation in a consanguineous relative. (2) Patients with breast cancer who meet one or more of the following criteriac: ① Age at onset ≤ 45 years; ② Age at onset ≤ 50 years and one consanguineous relatived who is also a breast cancer patient with age at onset ≤ 50 years and/or one or more consanguineous relatives who are ovarian epithelial/fallopian tube/primary peritoneal cancer patients of any age; ③ A single individual with 2 primary breast cancerse and first (3) A single individual with 2 primary breast cancerse and first onset age ≤ 50 years; (4) 2 or more consanguineous close relatives of any age with breast cancer and/or ovarian epithelial/fallopian tube/primary peritoneal cancer; (5) A consanguineous male close relative with breast cancer; combined with a past history of ovarian epithelial/fallopian tube/primary peritoneal cancer. (3) Patients with ovarian epithelial cancer/ fallopian tube cancer/ primary peritoneal cancer. (4) Patients with male breast cancer. (5) Have a family history of: a. Any of the above conditions in a consanguineous first- or second-degree relative; b. 2 or more patients with breast cancer (at least 1 with age of onset ≤ 50 years) and/or ovarian epithelial/fallopian tube/primary peritoneal cancer in a consanguineous third-degree relative. Note: a. Meeting 1 or more of the conditions suggests a possible hereditary breast cancer-ovarian cancer syndrome, necessitating specialized evaluation. When reviewing the patient’s family history, paternal and maternal relatives with cancer should be considered separately. Early-onset breast cancer and/or ovarian epithelial/fallopian tube/primary peritoneal cancer at any age suggest a possible hereditary breast-ovarian cancer syndrome, which in some families with hereditary breast-ovarian cancer syndrome also includes prostate cancer, pancreatic cancer, gastric cancer, and melanoma. b. Other considerations: individuals with a limited family history, such as <2 female first- or second-degree relatives, or female relatives >45 years of age, in which case the likelihood of carrying the mutation is often underestimated. Patients with triple-negative breast cancer with an age of onset ≤ 40 years should be considered for testing for BRCA1/2 gene mutations. c. Breast cancer includes invasive and intraductal cancers. d. Close relatives are defined as first-, second- and third-degree relatives. e. 2 primary breast cancers include bilateral breast cancers or 2 or more definite primary breast cancers of different origin in the same side of the breast.