Muscle aseptic inflammation is mainly due to increased vascular permeability as a result of various unfavorable factors, commonly acute injury, chronic strain, as well as aging and degeneration, among others. After the increase of vascular permeability, the inflammatory cells and inflammatory mediators in the blood vessels infiltrate into the tissue interstitium, resulting in aseptic inflammation of the tissue interstitium. This results in swelling, pain, and in severe cases, local dysfunction. Swelling is mainly due to inflammatory infiltration, and pain is due to inflammatory irritation, with corresponding painful symptoms produced by the action of inflammatory mediators. Painful symptoms are relieved at rest and worsened during high activity. Aseptic inflammation usually does not produce systemic symptoms, such as hypothermia, malaise, night sweats and other systemic toxic symptoms. The condition should be treated with rest and non-steroidal anti-inflammatory drugs, including oral and topical medications.