1.Blood sedimentation (ESR): It is mostly increased in the active stage of the disease. 2, C-reactive protein (CRP): the concentration increases in the early stage of inflammation, so the positive rate can reach 70%~80% in the active stage. 3, rheumatoid factor (RF): rheumatoid arthritis patients with a positive rate of 80%, RFFix (titer count), often more than 1: 80 meaningful, to determine the value of the disease is higher. 4, hemoglobin: rheumatoid arthritis often has mild or moderate anemia during the active phase. Serum iron and iron binding capacity may be normal or low. 5, rheumatoid arthritis patients on the effect of humoral immunity and cellular immunity: because of the existence of immune regulation disorders, so in the acute active phase, often visible humoral immune hyperactivity, especially the most obvious IgG increase, IgM, IgA changes are relatively small, complement C3 elevated, total complement decreased, circulating immune complex (CIC) generally in the stable phase when the content is reduced, there are some cases of cellular immunity There are some cases of low cellular immunity, especially the suppressive T cells are significantly reduced. 6. X-ray examination, early joint X-ray shows no special changes, only soft tissue swelling around the joint. Later, narrowing of the joint space and osteoporosis of the adjacent bones can be seen. In the late stage, fusion of the joint surfaces of the two bony ends and disappearance of the joint cavity can be seen, and even joint subluxation and osteoporosis of the bones adjacent to the deformed joint can be seen.