Vitamin D and multiple sclerosis Current opinion: Vitamin D is a hormone with multiple physiological effects, not only regulating serum calcium alone. For example, it is also involved in immune regulation. Reduced serum levels of vitamin D are associated with the development of many diseases and are related to the effectiveness and prognosis of disease treatment. Vitamin D deficiency increases the occurrence of multiple sclerosis, accelerates its progression and has a poor prognosis. According to American scholars, in normal healthy people, the concentration of vitamin D in the serum is between 75-100 nanomoles (nm)/L (30-40 ng/ml). In most patients, in order to achieve this level, 3000 international units (IU) of vitamin D supplementation is required daily; in order to maintain this level, 500-800 IU supplementation is required daily. 40,000 IU daily supplementation has been found to be safe for short periods of time. However, just how long to supplement? At what dose? Further research is still needed. Norwegian scholars believe that because osteoporosis is present early in the disease course of MS patients, serum levels of 25-hydroxylated vitamin D should be above 50 nm throughout the year. maintaining 75-125 nm maintains bone health with low disease activity. Therefore, they recommend that patients with multiple sclerosis supplement with at least 800 IU per day from fall to spring Therefore, they recommend: MS patients should supplement with at least 800 IU per day from fall to spring, with intermittent testing to maintain their target levels between 75 and 125 nm. Dutch scholars reported a female patient with multiple sclerosis, diagnosed in 1990. From 1998 to 2000, her walking ability was shortened from 20 km per day to only 1 km per day. The initial dose of 800 IU was gradually increased to 4000 IU in September 2004 and 6000 IU in September 2005, and vitamin D3 supplementation reduced muscle pain and improved walking ability. There were no adverse effects such as no hypercalcemia, hypercalciuria or kidney stone disease after 10 years of administration. However, malabsorption occurs because of possible intestinal problems, including calcium, which increases serum parathyroid hormone and hydroxylated vitamin D levels, and bone decalcification. Therefore, patients should be aware of regular assessment of vitamin D, calcium and magnesium intake, testing for intestinal problems and serum parathyroid hormone and calcium levels, bone condition, and urinary calcium and stones in the body to deal with possible problems. Spanish scholars, recently reviewed the literature and meta-analysis concluded that vitamin D supplementation for multiple sclerosis is inconclusive and needs further evaluation. Animal studies have also found that vitamin D supplementation can inhibit the development and progression of experimental metaplastic encephalomyelitis (an animal model of multiple sclerosis). However, in vitamin D gene-deficient mice, the disease was not aggravated but less severe. Animal experiments further demonstrated that sunlight exposure or ultraviolet radiation could modulate the immune response of animals to alleviate the disease. Therefore, vitamin D supplementation may have a role in regulating calcium, and it remains to be seen whether it can have immunomodulatory help in treating multiple sclerosis. Note: The contents here (including all of my website) are extracted from foreign literature. There are racial differences and individual differences in diseases, as well as individual differences in medications, so when reading the internet, it is for reference only and should not be copied and used. Be sure to consult your treating physician.