Nearly 25% of erectile dysfunction caused by drugs, causing ED drugs are as follows: anti-hypertensive drugs, antipsychotics, antidepressants, anticholinergics, antihistamines, H2 receptor antagonists, anti-androgen drugs, estrogens, corticosteroids, opiates, chemotherapy drugs. 1, hypertensive drugs Anti-hypertensive drugs cause ED most commonly. Almost all anti-hypertensive drugs can cause ED. can lead to a drop in blood pressure, resulting in reduced perfusion pressure in the cavernous body of the penis, reduced blood flow, affecting erection. Commonly, the following: (1) beta-blockers, betalactam, cause a decrease in blood testosterone levels, which affects sexual behavior through the 5-HT pathway of the central nervous system. Cardiotrophin, 320 mg orally daily, can cause erectile difficulties in 13.8% of patients. Atenolol causes ED is less common. Labetalol can cause abnormal penile erection, rarely reported metoprolol cause ED. (2) diuretics, thiazide diuretics often cause ED. ativan, 4-30 percent of patients taking it caused erectile dysfunction and decreased libido. The mechanism is that androstadine has an anti-androgenic effect, inhibiting the biosynthesis of androgens, causing decreased libido, breast development and erectile dysfunction. (3) vasodilators, hydrazinophthalazine, more than 200 mg per day, 5-10% of male patients with hypoactive sexual desire, ED. (4) sympathetic blockers, methyldopa causes ED incidence of 2-80%, colistin causes ED accounted for 4-41%, Risperdal 30-40% of the occurrence of ED (mechanism: inhibit the central nervous system, increase the level of prolactin, reduce libido.) (5) angiotensin-converting enzyme, guanethidine 24%. (5) angiotensin-converting enzyme inhibitors, calcium antagonists cause sexual dysfunction is rare. Angiotensin II receptor antagonists such as cloxacin have no adverse effect on erection. 2, gastrointestinal drugs Common drugs cimetidine (also known as metformin), ranitidine, nizatidine, mainly for the treatment of peptic ulcer, more and more case reports point to its ability to cause sexual dysfunction. The mechanism of action is anti-androgenic activity. Long-term use of cimetidine can appear ED, loss of libido and breast development. 3, antidepressants tricyclic, monoamine oxidase inhibitors, lithium agents. Commonly used drugs: promethazine, amitriptyline, chlorpromazine, new selective 5-hydroxytryptamine reuptake inhibitors, etc. can cause erectile dysfunction, abnormal ejaculation and lack of libido. Mechanism of action: interference with the conduction of autonomic impulses to erection and ejaculation. Lithium carbonate causes ED, related to the reduction of central dopa activity. 4, psychostimulants and narcotics The most common are alcohol, nicotine, cocaine, heroin, marijuana, etc.. People often question the impact of alcohol on erectile function, “after drinking alcohol is not more easily sexually aroused?” Here we ignore the difference between sexual desire and erection, alcohol can increase sexual desire, but it will affect erectile function and reduce the hardness of the penis erection. 5, anti-tumor drugs Anti-tumor drugs damage the gonads. Among them, cyclophosphamide, nitrogen mustard, vincristine, cytarabine and other drugs can cause erectile dysfunction or lack of sperm in men, and menstrual disorders and menopause in women. 6, prostate treatment drugs 5-alpha reductase inhibitors (Paulownia), inhibit the conversion of testosterone to active dihydrotestosterone, thus causing erectile dysfunction and reduced ejaculation. Commonly used drugs for the treatment of prostate cancer, anti-androgen drugs (Fuzeol, Comstock), competitively bind to androgen receptors, thus affecting the function of androgens, affecting libido, penile erection, ejaculation, etc. 7, cardiovascular drugs Anti-arrhythmic drugs: amiodarone (up to dragon). Anti-heart failure drugs: digoxin, grams to reduce blood testosterone levels, so that estrogen levels rise. 8, sedative drugs Commonly used antidepressants are barbiturates, phenothiazines, suppress libido and inhibit sexual arousal. 9, drugs that cause hyperprolactinemia Thiazides, opioids, methotrexate, reserpine, cimetidine (meclizine). 10, analgesics cocaine, pethidine, methadone long-term application can appear hypersexuality, ED. 11, hormonal drugs estrogen (estradiol, tonic gyal), progesterone acetate, corticosteroids can lead to hypersexuality and ED. 12, other categories (1) anticholinergic drugs: atropine, probenecid. (2) antihistamines: Benadryl, paracetamol, cimetidine, high-dose ranitidine. Erectile dysfunction caused by famotidine is rare. (3) Gastrofacial can cause hypersexuality and ED. (4) Carbamazepine, phenytoin sodium.