Ulcer disease or peptic ulcer is a common gastrointestinal disease that can occur in the esophagus, stomach or duodenum, or in the vicinity of the gastric-jejunal anastomosis or within the Meckel diverticulum containing the gastric mucosa, because gastric and duodenal ulcers are the most common, so generally the so-called peptic ulcers refer to gastric and duodenal ulcers. I. The mechanism of pain production is related to the following factors: 1. Inflammatory lesions in the ulcer and its surrounding tissues can increase the sensitivity of local visceral receptors and lower the pain threshold. 2. Increased local muscle tone or spasm; 3. Stimulation of the ulcer surface by gastric acid. Second, ulcer pain is characterized by: 1. chronic passage: except for a few patients who seek medical attention earlier after the onset of the disease, most of the disease has lasted for several years, a decade or longer. 2. Periodicity: Except for a few patients who do not recur after the first episode, most of them have recurrent episodes, with alternating periods of attack and remission in the course of the disease. This reflects the recurrent process of the ulcer cycle of acute activity, gradual healing and scar formation. The flare-up period can last for weeks or even months, and the remission period can last for months or years. The frequency of flare-ups and the duration of flare-ups and remission periods vary according to the individual patient and the development of the ulcer and the effectiveness of treatment and measures to consolidate the effect. Seizures may be related to the following triggers: season, mental stress, mood swings, dietary disorders or medications related to the onset of the disease, etc. A few may also have no obvious triggers. 3. Rhythmicity: ulcer pain is related to gastric acid stimulation, and there is a typical regular rhythm between pain and diet in clinical practice. Gastric ulcer pain mostly appears half an hour after a meal, lasts 1 to 2 hours, gradually disappears until the next meal and repeats the above pattern. Duodenal ulcer pain tends to appear 2 to 3 hours after a meal, lasts until the next meal, and is completely relieved by eating or taking acidulants. Abdominal pain usually appears before lunch or dinner and in the evening before bedtime or in the middle of the night, with fasting pain at night. When a gastric ulcer is located at the pyloric duct or when a duodenal ulcer coexists, the pain rhythm may be the same as that of a duodenal ulcer. When the rhythm of pain changes, the development of the disease should be considered to increase, or the emergence of complications. 4. Site of pain: Gastric ulcer pain is mostly located in the middle or to the left of the subxiphoid process, while duodenal ulcer is located in the middle or to the right of the epigastrium. The scope of pain is generally more limited, with localized pressure pain. The localization of visceral pain is vague, and the ulcer site cannot be determined by the pain location. If the ulcer is deep to the plasma membrane layer or is a penetrating ulcer, the pain may be diffused to the chest, left upper abdomen, right upper abdomen or back depending on the location of the penetrating part. 5. Nature and degree of pain: The degree of ulcer pain varies, and its nature depends on the patient’s pain threshold and individual differences. It can be described as hunger-like discomfort, dull pain, belching, pressure, burning or sharp pain and stabbing pain.