Tumor thermotherapy mainly refers to the therapeutic method of using the bio-thermal effect of non-ionizing radiation physical factors to make biological tissues heated up (usually 40~44℃) to kill tumor tissues or promote apoptosis of tumor cells so as to achieve the therapeutic purpose. It is the fifth major means of tumor treatment after surgery, radiotherapy, chemotherapy and biotherapy. In recent years, many researches have found that thermotherapy and certain chemotherapeutic drugs have obvious synergistic effect when they are used jointly, and have achieved remarkable results. Selection of thermo-chemotherapeutic drugs Not all the drugs have thermal sensitization effect, different authors due to the use of different cell lines and test conditions, the results of the study are not the same. Most authors recognize and have been confirmed to play a synergistic effect with the thermal therapy of platinum, adriamycin and other drugs. (1) Platinum is a commonly used clinical antitumor drug, which plays an important role in the first-line treatment regimen for common tumors of the digestive tract and gynecology. Platinum drugs play a cytotoxic role by binding to DNA, causing internal or inter-DNA cross-links and/or cross-links between DNA and proteins. Among them, cisplatin is one of the earliest drugs found to have a synergistic effect with hyperthermia, and it is also the most commonly used intraperitoneal perfusion drug in clinical practice. (2) Adriamycin is still one of the main antitumor drugs with strong cytotoxicity, and it is a specific blocking drug for mitotic S-phase of tumor cells, and S-phase is the most sensitive to heat; therefore, the combination of heat and chemotherapy can not only improve the sensitivity of chemotherapeutic drugs, but also enhance the killing effect of the tumor cells and improve the therapeutic efficacy; also reduce the dose of the drug, so as to alleviate the immediate and long-term adverse effects of chemotherapy. Adriamycin has a sensitizing effect on thermotherapy. (3) Other more researched and considered effective drugs include paclitaxel, hydroxycamptothecin, cyclophosphamide, mitomycin, etc. By combining with thermotherapy, it can improve the intracellular drug concentration, reduce the drug resistance of tumor cells, and enhance the cytotoxicity to reduce the adverse effects of chemotherapy. With the development of thermotherapy equipment and technological progress as well as the change of the concept of tumor thermobiology, regional deep thermotherapy and systemic thermotherapy have been gradually promoted both at home and abroad, and the combination of thermotherapy and chemotherapy in the treatment of tumors has gained great development, and thermochemotherapy has been applied in various ways in the clinic. (1) Combination of local hyperthermia and systemic chemotherapy: For the combination of regional hyperthermia and systemic chemotherapy in the lesion area for the treatment of middle and late-stage tumors, there have been many reports at home and abroad, and it has certain efficacy for some primary or metastatic tumors. (2) Local hyperthermia and body cavity perfusion chemotherapy: For malignant tumors in the abdomen and pelvis, even after radical surgery, there may still be extensive planting and metastasis of tumor cells. In the case of abdominal perfusion chemotherapy, the drug concentration in serum and abdominal fluid can differ by 100~1000 times. It is the combination of heat therapy, local chemotherapy and peritoneal lavage that is utilized in abdominal thermal perfusion chemotherapy, and therefore it has a better curative effect on middle and late stage abdominal tumors.