Author’s Note: Human beings are living beings and should conform to the laws of the biological world. This article talks about the understanding of medical therapeutics from a wide perspective of the biological world. It is also my understanding of Chinese medicine and the idea of combining Chinese and Western medicine. This is to answer the question of whether Chinese medicine can cure diseases and whether Chinese and Western medicine can be combined scientifically. Yang Feng, Department of Integrative Medicine, Henan Cancer Hospital Yang Feng, Department of Integrative Medicine, Henan Cancer Hospital Abstract Reaction is the basic form of diverse and complex biological life phenomena. Reaction is determined by the reactivity of organisms. Reaction and reactivity are the most universal and basic properties of the biological world, which are self-built and self-regulated instincts of organisms. The reactivity of organisms differs from species to species, from individual to individual, and from time to time and from state to state. The differences in reactivity are not only in the intensity of the reaction but also in the pathways of the reaction. In this paper, based on the basic properties of the biological world, and guided by the basic principle of self-construction and self-regulation of organisms, we summarize a large number of modern research results in medicine and biology, and deduce that human reactivity is the basis for the development of disease and treatment. It is also the key to understanding Chinese medicine and the bridge between Chinese and Western medicine. The authors propose the concept of “reaction pathway” based on the complexity of biology and quantum mechanics theory, and hope that the medical profession will pay attention to it and further research to confirm it. The theme words: Biology, Reaction, Reactivity, Disease treatment, Chinese medicine, Reactivity is a fundamental property of organisms and a basic condition for their survival. The regulatory response of organisms to external environmental changes and harmful factors determined by reactivity is the main mechanism for organisms to adapt to the environment, fight and avoid harm, reduce or eliminate its adverse effects on the organism, and maintain normal survival and reproduction. The strength of the response, the pathway and the outcome of the response depend on the reactivity of the organism. Therefore, reactivity and regulation of reactivity are the basic mechanisms of disease development and therapeutic regression. It is the basis of all preventive medicine and therapeutics. It is also the key to understanding Chinese medicine. I. Reactivity is the most universal and basic property of the biological world. Reactivity is a universal phenomenon in the biological world. Reactivity is the ability of organisms to self-construct, self-organize and self-regulate, and it is the most basic property of organisms. It is the basis for determining reactions. The essence of reaction is a series of targeted self-adjustments made by the organism after being stimulated, with the aim of reducing or eliminating damage to the organism. Through the reaction, the relationship with the environment is adjusted to achieve the purpose of adaptation to the environment. Such examples abound in the biological world. Plants respond differently to temperature, sunlight, drought, salinity, insect damage, trauma, etc. For example, in a drought environment, plants adjust their leaves to minimize water evaporation and their root systems will root down deeper into the ground to ensure water supply. In a high-salt environment, plants can adjust to the high-salt environment through regulation at the genetic level; in the event of pests and diseases, plants can synthesize some chemicals in their bodies to defend against them. This is especially true for animals, both lower and higher animals, which rely on their reactions to regulate their relationship with the surrounding environment in order to adapt to the natural world. There are various ways to react, and different organisms have different ways of reacting to different stimuli. In higher animals and humans, when the organism encounters biological factors, chemical and some physical damage, it will undergo a series of physiological and biochemical changes to eliminate and mitigate the damage by regulating the responses of various systems such as neuroendocrine, immune, enzymatic reactions and nutrient metabolism. The reactivity of organisms determines the occurrence, process and outcome of reactions, and only with reactivity can organisms survive. Therefore, reactivity is the most basic and universal property of organisms. There are differences in the reactivity of organisms. The reactivity of different species of organisms is different from each other, and the reactivity of different individuals of the same species is also different. The reactivity of different species is determined by their different structural, physiological and biochemical characteristics. Genetic variation over time has also led to genetic differences between individuals of the same genus, even among children of the same parents. Genetic differences lead to differences in neuroendocrine, immune, metabolic, nutrient absorption, and enzymatic reactions between individuals. This makes different individuals react very differently when they encounter external environmental events. Moreover, the reactivity of the same individual also varies in different stages and states. For example, according to the biological clock theory, the reactivity of humans and animals varies greatly at different times; the reactivity of the organism changes at different nutritional states, different psychosocial factors, different levels of fatigue, whether or not it is ill, at different stages of illness, whether or not it is menstruating, and in stressful states. When examining reactivity and disease, it is important that different individuals of the same genus and different stages and states of the same individual have different reactivity. Differences in biological reactivity are manifested in both response strength and pathways. Differences in response intensity are easy to understand; differences in response pathways are more difficult to express. First of all, it is important to realize that an organism is a dynamic open system with strict order, intricate and complex, which involves the whole body, and after being acted by an event (stimulus), the reaction will never affect only one tissue or one function, and proceed along one pathway. The world-renowned theoretical physicist Stephen Hawking has said to the American physicist Charles B. Hodgkin that he is not a “theoretical physicist”. Stephen Hawking, a world-renowned theoretical physicist, has commented on American physicist Charlie Feinman’s concept of historical summation. The idea is that a system has more than a single history in space-time, unlike what is usually assumed in classical non-quantum theory. Instead, it has all possible histories. ．．．．．． It is kind of like what is going to happen when you put a drop of ink on a piece of blotting paper. The ink particles will disperse along all the paths on the blotting paper. This quantum theory also applies to the biological world as well. There are many paths by which an organism responds to a factor stimulus of a certain intensity. For example, the stress response involves neuroendocrine, immune, nutrient metabolism, gene transcription, and other pathways (systems). For example, free radicals act on the organism, both in terms of damage to lipids, nucleic acids, proteins, and sugars, but also in relation to cell signaling, synthesis of certain substances in the body, in vivo detoxification, and defense mechanisms of the organism. After stimulation of an organism, the response proceeds along multiple pathways and its manifestation is the sum of multiple pathways. Since the functional state of each subsystem of the body is different in different individuals of the same species and in different stages and states of the same body, the results of the reactions of various pathways are also different, and the sum of the reactions of each pathway must also be different. Some pathways may not cause damage or mild damage to the body, while some pathways may cause serious damage to the body, and the final performance seems to be the result of a certain pathway reaction. It is the sum of different reaction pathways. In most cases, the reactivity of the organism can adjust the adaptability of the organism to the external environment, so that it has the ability to defend and mitigate the damage, and can survive under the constant aggression of harmful factors. However, differences in individual reactivity lead to the development of diseases in some individuals. The disease in turn leads to changes in the organism’s reactivity, forming a cascade that leads to disease progression and death. Therefore, reactivity is also an intrinsic cause of disease progression and regression. (i) Reactivity and disease occurrence When the organism is exposed to harmful factors and events, it is only in the normal genetic background that all parts of the organism function normally and in a coordinated manner to give the appropriate response, which is beneficial to the organism. However, due to the different reactivity of different individuals and different stages and states of the same organism, the reaction of some people appears to be too much or too little and develops along harmful pathways, which leads to diseases. Therefore, the difference in the reactivity of the organism determines the onset and severity of the disease. There are many such examples, for example, the same hepatitis B virus carrier, some people have very serious damage to liver function, while some people can carry for a long time without developing the disease; in the same environment and the same lifestyle in areas with a high incidence of cancer, only a very small number of people develop the disease while most people do not; the same body is not easy to catch a cold in general, but easy to catch a cold when fatigue, etc. Differences in reactivity can explain individual differences in disease onset. (2) Reactivity and disease development and regression Reactivity is not only the intrinsic basis of disease occurrence, but also the cause of disease development and regression. Reactivity determines the outcome of the reaction, which in turn changes the reactivity of the organism, and the new reactivity determines the new reaction state, and the outcome of the secondary reaction changes the reactivity of the organism, forming the basis for a new round of reaction. The degree of damage to the body’s function and structure varies significantly due to differences in the reactivity of affected individuals and the effect of treatment on reactivity. Therefore, reactivity determines the development and progression of the disease. For example, most patients with the same upper respiratory tract infection have a good outcome, while very few develop glomerulonephritis or rheumatoid disease; some patients with the same serious infectious disease develop multiple organ failure, while others have a good outcome; the same patient with coronary artery disease has a different risk of infarction due to different reactivity when exposed to the same intensity of triggers; even in hereditary and metabolic diseases, the development of the disease is affected by reactivity. The course of disease development is also influenced by differences in reactivity. The second strike doctrine proposed in the study of multiple organ failure is a powerful interpretation of the development and regression of disease determined by the reactivity of the body. Fourth, regulatory reactivity is the root of disease prevention and treatment. Reactivity determines the occurrence, development and regression of diseases. Then, regulating reactivity is the fundamental method of disease prevention and treatment. The progress of clinical medicine in recent years has been related to finding effective methods to regulate the reactivity of the body. (a) Regulation of reactivity and disease prevention Vaccination has become an important method for the effective prevention of microbial infections in humans. The mechanism is to change the reactivity of the body by pre-administration of an appropriate amount of antigen, so that the body can effectively clear or be in a non-reactive state when exposed to such antigen again, thus avoiding the occurrence of disease. Direct injection of antisera, immune cells, cytokines, etc. in the form of secondary immunotherapy is also used to prevent and control diseases by regulating reactivity. Other therapies such as nutritional therapy, psychotherapy, exercise therapy and other health care therapies are all aimed at strengthening the body and preventing diseases by regulating the body’s reactivity. (2) Regulation of responsiveness and disease treatment Analysis of various methods of disease treatment are inseparable from the regulation of body responsiveness. The progress of clinical medicine in recent years has been achieved by the elucidation of the mechanism of biological reactivity and the discovery and application of active substances for regulating reactivity. All biological therapies work by regulating responsiveness; the success of organ transplantation is achieved by regulating responsiveness; the regulation of immune function in the treatment of autoimmune diseases; the modification of airway responsiveness in the treatment of bronchial asthma; advances in clinical nutrition are based on the discovery of the regulatory effect of nutrients on organism responsiveness; the biological targeting of malignant tumors is achieved by regulating excessive growth factors and receptors; endocrine The principle of endocrine therapy, neurotransmitter and receptor therapy, etc. is to regulate the body’s responsiveness; surgical procedures, with stress and nutrition problems, are also inseparable from the regulation of responsiveness. Even for infectious diseases, the regulation of the body’s immune function and inflammatory factors is also present in the treatment, and for non-infectious diseases that are mainstream today, the regulation of body reactivity is the main treatment method, and is always present. As the reaction and reactivity of the body interact with each other to determine the development of the disease, in the cascade reaction after the onset of the disease, the influence of the antecedent reaction and its damage results, therapeutic drugs and methods can change the reactivity of the body, which in turn determines the degree of damage to the body by the next level reaction. Regulating the reactivity of the organism before the onset of disease can reduce the onset of disease, and effectively regulating the reactivity of different stages and states in the disease progression can not only reduce the damage of the reaction, but more importantly, affect the reactivity of the organism at the next stage, which can eliminate and weaken the next-level reaction and cut off the pathological transformation chain. Therefore, it is important to grasp the reactivity of the body at different stages of disease development, and regulate the reactivity of the body in a targeted manner while treating the cause of the disease, in order to achieve significant therapeutic effects. The treatment method of Chinese medicine is the specific application of regulating reactivity in clinical practice. Identification is to determine the reactivity of different individuals and different stages and states of the same body. The evidence of TCM is a specific classification of the reactivity of the body. This classification reflects not only the level of reactivity, but also the different paths of reaction. The same disease can have different reactivity for different individuals, at different stages and in different states, and the same reactive changes can occur in different diseases, which is the reason why one disease has multiple certificates and one certificate has multiple diseases. The treatment is to adjust for different reactivity, the same treatment for the same disease and different treatment for different diseases. The same disease is treated differently, and different diseases are treated together. By applying treatment through identification, the reactivity of the body can be beneficially adjusted, so as to reduce or eliminate the damage caused by pathogenic factors to the body and stop the progress of the disease. Acupuncture, acupuncture point therapy and massage in TCM are also specific applications of regulating reactivity. This treatment method, which fully embodies the principle of individualized and phased treatment, is more targeted and scientific compared with Western medicine. Regulatory responsiveness is not only the basis of disease prevention and treatment in modern medicine, but also the key to understanding Chinese medicine and the bridge between Chinese and Western medicine. REFERENCES 1. Li Shaowen, ed. Ecological Biochemistry. 2001; 222~267 332~365 2. Translated by Yipeng Cai. Animal Ecology. Science Press. 2000. 3. Xu Jinlin, Xu Qin, Chen Chun. Edited by. Principles of modern genetics. Science Press. 2001. 816~848 4. He Shaoxiong, ed. Time pharmacology and time therapeutics. Tianjin Science and Technology Press. 1998. 5. Lin, Shu-Xin, Liu, Jun-Ze, eds. Pathophysiology. Fourth Military Medical University Press. 2003. 6. Du Xinxin. Wu, Zhongchao. 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