Coughing is a clinical symptom rather than a disease, and coughing with hoarseness depends on the specific situation to determine the treatment measures. First, cough with hoarseness caused by upper respiratory tract infection, which is caused by upper respiratory tract infection complicated by vocal fold inflammation, can mostly be treated symptomatically. In the absence of sputum or minimal sputum, appropriate cough suppressants, such as dextromethorphan, are used to relieve cough symptoms. With the relief of cough symptoms, the vocal cords are gradually repaired and the hoarseness can disappear, which is one of the most common cases. Second, cough symptoms caused by other respiratory infections, such as bronchitis, pneumonia, bronchiectasis, etc., require antibiotics to control the respiratory infections, and the cough and hoarseness can be relieved. Third, hoarseness caused by problems with the vocal cords themselves, such as hoarseness caused by vocal cord nodules and vocal cord polyps, requires surgical treatment in addition to relieving cough symptoms. Fourthly, if the cough is persistent and accompanied by hoarseness, we should be alert to whether the hoarseness is caused by bronchial lung cancer invading the laryngeal nerve, which requires anti-tumor treatment. In conclusion, cough with hoarseness requires targeted treatment according to various causes.