Whether a person with a chronic disease can be vaccinated depends on factors related to the type and stage of the chronic disease and the nature of the vaccine, and should not be viewed in absolute terms. Usually some kinds of chronic diseases do not affect vaccination if they are well controlled by medication, but there are some special cases that may affect vaccination: 1. Special types of chronic diseases: vaccines generally work to activate the human immune system to produce antibodies against a certain disease, and certain immune system diseases that lead to hyper- or impaired immune function may cause an over-reaction or affect antibody production. Certain diseases with liver and kidney damage may have certain effects on the metabolism after vaccination, so special types of chronic diseases should be vaccinated with caution; 2. Active period of chronic diseases: Usually, if chronic diseases are well controlled, such as hypertension and hyperlipidemia, vaccination can be administered, but if they are in the active or progressive period of chronic diseases, they are also contraindicated for vaccination and should not be administered; 3. Vaccination; 3. Nature of vaccine: If inactivated vaccination is given, generally speaking, vaccine toxicity is lower and stimulation to human body is less. Except for the cases of absolute contraindication, most of the stable periods of chronic diseases are basically not affected by vaccination, while attenuated vaccines should be administered with caution to patients with chronic diseases. Due to individual differences in the population, there is no such thing as a chronic disease that can definitely be vaccinated at the time of vaccination. If a person is suffering from a chronic disease, he or she should explain the situation to the medical worker at the vaccination site before vaccination and judge whether to proceed with vaccination or not based on the advice of the medical staff at the vaccination site.