How is interventional arterial chemotherapy better than conventional intravenous chemotherapy?

       Currently, malignant tumors have become the number one killer that threatens human life and health. Chemotherapy has been widely used as a revolutionary treatment for malignant tumors. However, the side effects of chemotherapy often make patients “fearful”. In the traditional concept, chemotherapy is almost equal to white blood cell decline, nausea, vomiting and hair loss.  In addition to its own pharmacological effects and the sensitivity of tumor to chemotherapy drugs, the efficacy of chemotherapy is also related to the concentration of chemotherapy drugs in the tumor area and the contact time between chemotherapy drugs and tumor. Studies have shown that after the drugs are injected into the body through the veins, they are pumped out to the arteries through the heart and shunted to the whole body through the branches of the arteries step by step, during this process, the chemotherapeutic drugs are fully diluted and mixed by the blood, while reaching the tumor area, most of the chemotherapeutic drugs are shunted to the non-tumor organs. The amount of biologically active drugs containing free radicals by the time they reach the target organs is reduced, resulting in lower drug efficacy.  The drug concentration in the solid tumor area mainly depends on the local blood flow. If the blood supply to the organ is large and the tumor is rich in blood vessels, the drug concentration in the tumor area is relatively high; however, the blood flow of a certain tumor is relatively stable in a certain period of time, so the only way to increase the drug concentration in the tumor area is to increase the drug injection volume and injection rate under intravenous administration. However, usually the side effects of the drug are proportional to its concentration, so it is difficult to increase the drug concentration by intravenous administration.  By infusing chemotherapeutic drugs directly into the tumor or the tumor-bearing organs through the tumor-nourishing arteries with a thin catheter, the local drug concentration is greatly increased, avoiding the disadvantage that a very small amount of drug enters the tumor only after the intravenous infusion flows through the whole body first. The drugs flowing to other parts of the body also play the role of chemotherapy. Therefore, the local tumor killing power is high while the systemic side effects are low. At the same time, arterial intervention technology can embolize chemotherapy drugs and particles in the tumor, so that the drugs can play a continuous role and cause ischemic necrosis to the tumor. This technique has been applied to various malignant tumor patients with miraculous clinical efficacy, such as transbronchial artery infusion chemotherapy and embolization for lung cancer, transhepatic artery chemoembolization for liver metastases of liver cancer, transmesenteric artery infusion chemotherapy for gastric cancer and colorectal cancer to control tumor and relieve intestinal obstruction, gynecological tumor and bone tumor intervention, etc. The efficacy of transarterial infusion chemotherapy for various tumors is remarkable, and the side effects are significantly reduced, basically without the pain of intravenous chemotherapy, even replacing intravenous chemotherapy and surgery, which has been widely recognized by the medical profession and is worth promoting and popularizing to tumor patients.